N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex-Catalyzed Direct C-H Bond Arylation of (Benz)imidazoles with Aryl Chlorides
N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex-Catalyzed Direct C-H Bond Arylation of (Benz)imidazoles with Aryl Chlorides
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DOI：
10.1021/jo5010058
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发表时间：
2014-06-20
影响因子：
3.6
通讯作者：
Shao, Li-Xiong
中科院分区：
文献类型：
--
作者：
Gu, Zheng-Song;Chen, Wen-Xin;Shao, Li-Xiong
在NHC-Pd（II）-Im配合物存在下，（杂）芳基氯可通过C H键的直接芳基化作用有效地将（苯并）咪唑类化合物官能化.在最佳反应条件下，采用不同的活化、未活化和失活的（杂）芳基氯作为芳基化试剂，以较高的收率合成了2-（杂）芳基（苯并）咪唑类化合物，为（苯并）咪唑类化合物的C-H键直接芳基化提供了一种简便可行的方法.
(Benz)imidazoles can be efficiently functionalized by (hetero)aryl chlorides via direct C H bond arylation in the presence of a well-defined NHC-Pd(II)-Im complex. Under the optimal conditions, various activated, unactivated, and deactivated (hetero)aryl chlorides were successfully applied as the arylating reagents to achieve the 2-(hetero)aryl (benz)imidazoles in acceptable to high yields, giving a facile and alternative methodology for the direct C H bond arylation of (benz)imidazoles.