Pathbase and the MPATH Ontology: Community Resources for Mouse Histopathology
Pathbase and the MPATH Ontology: Community Resources for Mouse Histopathology
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DOI：
10.1177/0300985810374845
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发表时间：
2010-11-01
影响因子：
2.4
通讯作者：
Sundberg, J. P.
中科院分区：
文献类型：
--
作者：
Schofield, P. N.;Gruenberger, M.;Sundberg, J. P.
Pathbase是小鼠组织病理学图像数据库，作为一种资源开发，可免费访问实验室小鼠背景和突变品系中病变的代表性图像。当用于突变小鼠的诊断检查或表型分析时，它可以为那些无法接触到经验丰富的病理学家的人提供“虚拟的第二意见”。这是一个社区资源，它促进了全球病理学社区成员之间的专业知识和数据共享。MPATH-小鼠病理学本体-一起开发的Pathbase的注释图像，现在代表了一个重要的资源编码的诊断，允许复杂的数据检索和计算分析小鼠表型。在这篇文章中，MPAT的结构和使用进行了讨论，沿着当前和未来的挑战，为突变小鼠表型的编码。
Pathbase, the database of mouse histopathology images, was developed as a resource to provide free access to representative images of lesions in background and mutant strains of laboratory mice. When utilized with diagnostic workups or phenotyping of mutant mice, it can provide a "virtual second opinion" for those working without access to groups of experienced pathologists. This is a community resource, and it facilitates the sharing of expertise and data among members of the pathology community worldwide. MPATH-the mouse pathology ontology-was developed alongside Pathbase for the annotation of images and now represents an important resource for the coding of diagnoses, permitting sophisticated data retrieval and computational analysis of mouse phenotypes. In this article, the structure and use of MPATH is discussed, along with current and future challenges for the coding of mutant mouse phenotypes.