Ovine pulmonary adenocarcinoma: a large animal model for human lung cancer.
Ovine pulmonary adenocarcinoma: a large animal model for human lung cancer.
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DOI：
10.1093/ilar/ilv014
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发表时间：
2015-05
期刊：
影响因子：
2.5
通讯作者：
G. Youssef;W. Wallace;M. Dagleish;C. Cousens;David J. Griffiths
中科院分区：
文献类型：
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作者：
G. Youssef;W. Wallace;M. Dagleish;C. Cousens;David J. Griffiths
肺癌是全球癌症死亡的主要原因。最近在了解这种疾病的分子发病机制方面取得的进展导致了针对特定患者群体的新的治疗策略。需要进一步的研究来提供诊断和治疗方面的更多进展。动物模型是研究肺癌致癌的有价值的工具，特别是在疾病的早期阶段，那里的组织很少从人类病例中获得。传统上，小鼠被用来研究体内肺癌，并有各种自发和转基因模型可用。然而，人们认识到，其他物种也可能为癌症研究提供信息。绵羊肺腺癌(OPA)是一种由逆转录病毒感染引起的绵羊自然发生的肺癌，具有与人类腺癌相似的组织学形态和共同的细胞信号通路激活等特征。此外，人类肺的大小和组织结构与绵羊肺的大小和组织结构比与小鼠肺的大小和组织结构更接近，这有利于在绵羊身上进行实验，这是小鼠所不具备的。因此，OPA为研究肺癌的发展提供了机会，可以补充传统的小鼠模型。在这里，我们描述了OPA作为人类肺腺癌模型的潜在应用，重点介绍了各种可用的体内和体外实验系统。
Lung cancer is the leading cause of cancer deaths worldwide. Recent progress in understanding the molecular pathogenesis of this disease has resulted in novel therapeutic strategies targeting specific groups of patients. Further studies are required to provide additional advances in diagnosis and treatment. Animal models are valuable tools for studying oncogenesis in lung cancer, particularly during the early stages of disease where tissues are rarely available from human cases. Mice have traditionally been used for studying lung cancer in vivo, and a variety of spontaneous and transgenic models are available. However, it is recognized that other species may also be informative for studies of cancer. Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring lung cancer of sheep caused by retrovirus infection and has several features in common with adenocarcinoma of humans, including a similar histological appearance and activation of common cell signaling pathways. Additionally, the size and organization of human lungs are much closer to those of sheep lungs than to those of mice, which facilitates experimental approaches in sheep that are not available in mice. Thus OPA presents opportunities for studying lung tumor development that can complement conventional murine models. Here we describe the potential applications of OPA as a model for human lung adenocarcinoma with an emphasis on the various in vivo and in vitro experimental systems available.