Retrograde and anterograde object recognition in rats with hippocampal lesions
Retrograde and anterograde object recognition in rats with hippocampal lesions
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DOI：
10.1002/hipo.10154
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发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
Mumby, DG
中科院分区：
文献类型：
--
作者：
Gaskin, S;Tremblay, A;Mumby, DG
对海马体结构细胞毒性损伤(HPC)大鼠的逆行和顺行物体识别记忆进行了评估，采用了一种基于大鼠花更多时间探索新物体而不是熟悉物体的自然倾向的范式。允许大鼠在手术前5周或1周连续5天每天对样本物体进行5分钟的探索。手术后，在自由选择的情况下，通过比较探索样本和新物体所花费的时间来评估逆行识别。对照组大鼠探索新对象的时间比两个手术前时间段的样本对象更多，而HPC损伤的大鼠不区分手术前两个时间段的新对象和样本对象。尽管HPC损伤的大鼠在逆行再认测试中存在缺陷，但在顺行再认测试中表现出与对照组大鼠一样的表现，表现出对新对象的强烈探索偏好，保留延迟为15分钟或24小时。这一发现表明，海马区外回路能够支持对象识别，但前提是HPC不参与编码与对象的原始遭遇。(C)2003年Wiley-Liss，Inc.
Retrograde and anterograde object-recognition memory was assessed in rats with cytotoxic lesions of the hippocampal formation (HPC), using a paradigm based on the natural tendency of rats to spend more time exploring novel objects than familiar objects. The rats were allowed to explore a sample object for 5 min/day on 5 consecutive days, either 5 weeks or I week before surgery. After surgery, retrograde recognition was assessed by comparing the amount of time spent exploring the sample versus a novel object in a free-choice situation. Control rats spent more time exploring the novel object than the sample objects from both presurgery time periods, whereas rats with HPC lesions did not discriminate between the novel objects and sample objects from either presurgery time period. Despite their deficits on the retrograde recognition test, the rats with HPC lesions performed like control rats on anterograde recognition tests, displaying a strong exploratory preference for novel objects over sample objects, with retention delays of either 15 min or 24 h. The findings suggest that extrahippocampal circuitry is capable of supporting object recognition, but only if the HPC does not participate in encoding the original encounter with the object. (C) 2003 Wiley-Liss, Inc.