Extrapulmonary tuberculosis in immunocompetent adults
Extrapulmonary tuberculosis in immunocompetent adults
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DOI：
10.1080/00365540410025339
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发表时间：
2004-12-01
影响因子：
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通讯作者：
Calangu, S
中科院分区：
文献类型：
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作者：
Cagatay, AA;Caliskan, Y;Calangu, S
结核病仍然是发病率和死亡率的一个重要原因。虽然结核病通常攻击肺部，但其他器官也可能受到影响，导致肺外结核（EPT）或播散性结核病。本研究回顾性分析了1991年1月1日至2003年6月30日期间252例EPT患者的发病率、临床部位和危险因素。EPT被定义为临床、实验室、影像学和/或组织病理学证据，表明分枝杆菌感染发生在肺门淋巴结或肺实质以外的部位。在我们的研究组中，发现结核性淋巴结炎（36.5%）是EPT最常见的临床表现。根据世卫组织的报告，119例（47.2%）患者出现严重形式的EPT， 133例（52.8%）患者出现较轻形式的EPT。有肺结核病史是发生EPT的危险因素（p < 0.05）。研究表明，EPT仍然是一个公共卫生问题。这些发现提示肺结核可能在EPT的发展中起关键作用。考虑到可接受的不良反应且无复发的EPT患者可选择12个月的治疗。
Tuberculosis continues to be a significant cause of morbidity and mortality. Although tuberculosis usually attacks the lungs, other organs can also be affected, leading to extrapulmonary tuberculosis (EPT) or disseminated tuberculosis. This study retrospectively analysed the incidence, clinical sites and risk factors for EPT in 252 patients with EPT between 1 January 1991 and 30 June 2003. EPT was defined as clinical, laboratory, imaging, and/or histopathological evidence of mycobacterial infection in a site other than hilar lymph nodes or lung parenchyma. In our study group, tuberculous lymphadenitis (36.5%) was found to be the most common clinical presentation of EPT. 119 ( 47.2%) patients developed the severe form of EPT, according to the WHO report, and 133 (52.8%) patients developed the less severe form. A case history of pulmonary tuberculosis was found to be a risk factor for the development of EPT (p < 0.05). The study showed that EPT is still a public health problem. These findings suggested that pulmonary tuberculosis may play a critical role in the development of EPT. 12-month therapy may be chosen in patients with EPT considering acceptable adverse effects without relapses.