Partial tuning of motor cortex neurons to final posture in a free-moving paradigm
Partial tuning of motor cortex neurons to final posture in a free-moving paradigm
复制标题
DOI：
10.1073/pnas.0511139103
复制
发表时间：
2006-02-21
影响因子：
11.1
通讯作者：
Graziano, MSA
中科院分区：
文献类型：
--
作者：
Aflalo, TN;Graziano, MSA
使用多样化且自然的手臂运动组对猴脑中的运动皮层神经元进行了测试。在这一系列整体运动中，神经元对每次运动结束时手臂所达到的多关节姿势表现出有限但显着的调节程度。进一步支持神经元部分调整到最终姿势的假设，神经元偏好的姿势与相同皮质部位的电刺激引起的姿势显着匹配。然而，即使通过最终姿势模型，神经元活动的许多变化仍然无法解释，因此其他变量一定对神经元的反应曲线有贡献。一种可能性是，运动皮层神经元会适应与动物正常行为库相关的各种运动参数，因此，任何一个参数都只能解释有限的神经元差异。
Motor cortex neurons in the monkey brain were tested with a diverse and naturalistic arm movement set. Over this global set of movements, the neurons showed a limited but significant degree of tuning to the multijoint posture attained by the arm at the end of each movement. Further supporting the hypothesis that the neurons are partially tuned to end posture, the postures preferred by the neurons significantly matched the postures evoked by electrical stimulation of the same cortical sites. However, much of the variance in neuronal activity remained unexplained even by the end-posture model, and thus other variables must have contributed to the response profile of the neurons. One possibility is that motor cortex neurons become tuned to the wide variety of movement parameters that are relevant to the animal's normal behavioral repertoire, and, therefore, any one parameter accounts for only a limited amount of neuronal variance.