Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension
Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension
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DOI：
10.1161/01.cir.97.19.1907
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发表时间：
1998-05-19
期刊：
影响因子：
37.8
通讯作者：
Kimball, TR
中科院分区：
文献类型：
--
作者：
Daniels, SR;Loggie, JMH;Kimball, TR
背景-左心室肥厚已被确定为成人心血管疾病的独立危险因素。最近的研究通过确定LV质量指数的临界点为51 g/m（27）来改善这种关系，表明风险增加，并定义与风险增加相关的LV几何模式。本研究的目的是评估严重的左心室肥厚和左心室几何结构的儿童和青少年原发性高血压。方法和结果，一个横断面研究的年轻患者（n=130）与持续的血压升高高于第90百分位数进行。19例患者（14%）的左心室质量大于第99百分位数;其中11例也高于成人临界点51 g/m（27）。男性、体重指数较大的受试者和在最大运动量时心率较低的受试者在最大运动量时的心率差异有显著性（P
Background-Left ventricular (LV) hypertrophy has been established as an independent risk factor for cardiovascular disease in adults. Recent research has refined this relationship by determining a cutpoint of 51 g/m(27) for LV mass index indicative of increased risk and defining LV geometric patterns that are associated with increased risk. The purpose of this study was to evaluate severe LV hypertrophy and LV geometry in children and adolescents with essential hypertension.Methods and Results-A cross-sectional study of young patients (n=130) with persistent blood pressure elevation above the 90th percentile was conducted. Nineteen patients (14%) had LV mass greater than the 99th percentile; 11 of these were also above the adult cutpoint of 51 g/m(27). Males, subjects with greater body mass index, and those who had lower heart rate at maximum exercise were at significantly (P