Bivariate isotonic design for dose-finding with ordered groups
Bivariate isotonic design for dose-finding with ordered groups
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DOI：
10.1002/sim.2312
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发表时间：
2006-06-30
影响因子：
2
通讯作者：
Wang, Kai
中科院分区：
文献类型：
--
作者：
Ivanova, Anastasia;Wang, Kai
我们考虑了剂量发现问题，其中受试者可以被分成两个可能对毒性具有不同敏感性的群体。目标是找到每个人群的最大耐受量。针对这个问题，我们提出了一种非参数设计方法。毒性使用双变量保序回归估计器进行估计。将新设计与两样本连续重评法进行了比较。版权所有(C)2005 John Wiley&Sons，Ltd.
We consider the problem of dose-finding where subjects can be stratified into two populations with possibly different susceptibility to toxicity. The goal is to find the maximally tolerated dose for each population. We propose a non-parametric design for this problem. Toxicity is estimated using the bivariate isotonic regression estimator. The new design is compared with the two-sample continual reassessment method. Copyright (c) 2005 John Wiley & Sons, Ltd.