Pro-inflammatory immunological effects of adipose tissue increase the risk of food allergy in obesity
Pro-inflammatory immunological effects of adipose tissue increase the risk of food allergy in obesity
复制标题
脂肪组织的促炎免疫作用会增加肥胖者食物过敏的风险
DOI：
--
复制
发表时间：
--
影响因子：
1.8
通讯作者：
Huilian Che
中科院分区：
文献类型：
--
作者：
Xiaoya Guo;Huilian Che
在过去的三十年里，肥胖人数稳步上升。慢性低度炎症状态和免疫系统的非特异性激活极大地促进了肥胖相关免疫学的发展。食物过敏是一种免疫反应异常的炎症性疾病，与肥胖有一定的关系。肥胖不仅直接导致脂肪组织中过敏相关免疫细胞的失衡，还通过影响脂肪细胞分泌的过敏相关细胞因子和脂肪组织中过氧化物酶体增殖物激活受体γ（peroxisome proliferator-activated receptor γ，PPARγ）的表达而间接导致这一结果。本文从肥胖症中脂肪组织的促炎免疫作用开始，并解释肥胖如何增加食物过敏的风险。
Over the past three decades, the number of obese people has risen steadily. The chronic low-grade.inflammatory state and the non-specific activation of the immune system have contributed greatly to the.development of obesity-related immunology. Food allergy is a kind of inflammatory disease with abnormal.immune response, and it has a certain relationship with obesity. Obesity not only directly causes imbalance of.allergic-related immune cells in adipose tissue, but also indirectly causes this consequence through affecting.expression of allergy-related cytokines secreted by adipocytes and peroxisome proliferator-activated receptor.gamma (PPARγ) in adipose tissue. This article begins with the pro-inflammatory immunological effects of.adipose tissue in obesity, and explains how obesity increases the risk of food allergy.