Epithelial cell fate following lung injury.
Epithelial cell fate following lung injury.
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DOI：
10.1586/17476348.2.5.573
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发表时间：
2008-10-01
影响因子：
3.9
通讯作者：
Nakayama, Katsutoshi
中科院分区：
文献类型：
--
作者：
Kuwano, Kazuyoshi;Araya, Jun;Nakayama, Katsutoshi
肺上皮是各种肺部疾病中肺损伤的主要部位。上皮细胞死亡被认为是肺损伤的初始事件，随后是重塑过程。当肺损伤程度较轻时，受损组织将正常修复，而过度的细胞死亡可能导致不可修复的肺损伤和重塑过程。上皮细胞和内皮细胞的存活和恢复以及炎症细胞的消退似乎是正常组织修复的关键。本文综述了近年来对各种肺部疾病肺损伤后细胞死亡机制的认识，并讨论了新的调控策略。对细胞死亡及其调控机制的进一步了解可能会导致对肺损伤的有效治疗的发展。
Lung epithelium is the primary site of lung damage in various lung diseases. Epithelial cell death has been considered to be the initial event in lung injury and is followed by remodeling processes. When the degree of lung injury is mild, damaged tissue will be repaired normally, whereas excess cell death may lead to irreparable lung damage and remodeling processes. The survival and recovery of epithelial and endothelial cells, and the resolution of inflammatory cells appear to be key for normal tissue repair. We review the recent advances in the understanding of mechanisms of cell death following lung injury in various lung diseases and discuss its regulation by novel strategies. Further understanding of mechanisms of cell death and its regulation may lead to the development of effective treatments against lung injury.