The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
复制标题
DOI：
10.1111/all.12955
复制
发表时间：
2016-10-01
期刊：
影响因子：
12.4
通讯作者：
van Hage, M.
中科院分区：
文献类型：
--
作者：
Apostolovic, D.;Sanchez-Vidaurre, S.;van Hage, M.
我们调查了140例猫致敏的瑞典患者对猫Lipocalin Fel d 7的致敏情况，并阐明了其过敏活性和与狗Lipocalin CaN F 1的交叉反应。在140例患者中，65例患者的IgE对rFel d 7有反应，其中60例同时存在对rcan f 1的IgE。RFel d7体外激活嗜碱性粒细胞并抑制IgE与rcan f1的结合，而rcan f1抑制7例rfel d7的IgE结合。FEL d 7和CaN F 1在蛋白质结构上有很高的相似性，用交叉反应的抗血清发现了共同的表位。在瑞典猫过敏人群中，fel d 7是一种常见的过敏原，它与can f 1发生交叉反应，可能会导致猫的症状，但也会导致狗过敏的患者出现症状。
We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.