Comparison of Cardiovascular Protective Effects of Tropical Seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on High- Cholesterol/High-Fat Diet in Rats
Comparison of Cardiovascular Protective Effects of Tropical Seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on High- Cholesterol/High-Fat Diet in Rats
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DOI：
10.1089/jmf.2008.1212
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发表时间：
2010-08-01
影响因子：
2.4
通讯作者：
Mustapha, Noordin Mohamed
中科院分区：
文献类型：
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作者：
Matanjun, Patricia;Mohamed, Suhaila;Mustapha, Noordin Mohamed
本研究旨在研究红色、绿色和棕色热带海藻Kappaphycus alvarezii（或Eucheuma cottonii）、Caulerpa lentillifera和马尾藻（Sargassum polycystum）对高胆固醇/高脂肪（HCF）饲料喂养的大鼠体内心血管保护作用的比较。16周后，体重260 ~ 300 g的雄性Sprague-Dawley大鼠体重、血浆总胆固醇（TC）、血浆低密度脂蛋白胆固醇（LDLC）、血浆甘油三酯（TG）、脂质过氧化、红细胞谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶水平均显著升高。在HCF日粮中添加5%海藻可显著降低血浆TC（-11.4% ~ -18.5%）、LDL-C（-22% ~ -49.3%）和TG（-33.7% ~ -36.1%）水平，并显著提高HDL-C水平（16.3 ~ 55%）。其中，多囊藻抗肥胖和血液GSH-Px性能最好，海苔抗高脂血症和体内抗氧化效果最好，扁豆藻降低血浆TC效果最好。所有海藻均显著降低HCF大鼠的体重增加、红细胞GSH-Px和血浆脂质过氧化水平。
This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260-300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDLC), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (-11.4% to -18.5%), LDL-C (-22% to -49.3%), and TG (-33.7% to -36.1%) levels and significantly increased HDL-C levels (16.3-55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best anti-hyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats.