Reduction of methionine selenoxide to selenomethionine by glutathione
Reduction of methionine selenoxide to selenomethionine by glutathione
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DOI：
10.1006/abbi.1997.0462
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发表时间：
1998-01-01
影响因子：
3.9
通讯作者：
Sies, H
中科院分区：
文献类型：
--
作者：
Assmann, A;Briviba, K;Sies, H
硒代蛋氨酸是蛋白质中代替蛋氨酸的氨基酸，与氧化剂（例如过氧亚硝酸盐，炎症状态下产生的生物氧化剂）有效反应，产生氧化产物蛋氨酸硒氧化物。本工作描述了在利用两当量硫醇的化学计量反应中，谷胱甘肽快速有效地将硒氧化物还原为硒代蛋氨酸，这种非酶促反应建立了防线蛋白质中的硒代蛋氨酸残基通过普遍存在的硫醇谷胱甘肽维持，从而对抗过氧亚硝酸盐或其他氧化剂。 (C) 1998 年学术出版社。
Selenomethionine, an amino acid occurring in proteins in place of methionine, reacts efficiently with oxidants, e.g., peroxynitrite, a biological oxidant generated in inflammatory states, to produce the oxidation product, methionine selenoxide, The present work describes the rapid and efficient reduction of the selenoxide to selenomethionine by glutathione in a stoichiometric reaction utilizing two equivalents of thiol, This nonenzymatic reaction establishes a defense line against peroxynitrite or other oxidants by selenomethionine residues in proteins, maintained by the ubiquitous thiol, glutathione. (C) 1998 Academic Press.