Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress
Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress
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DOI：
10.1163/156856005774423863
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发表时间：
2006
影响因子：
5.8
通讯作者：
A. Yanaka;Songhua Zhang;Masafumi Tauchi;Hideo Suzuki;T. Shibahara;Hirofumi Matsui;Akira Nakahara;N. Tanaka;Masayuki Yamamoto
中科院分区：
文献类型：
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作者：
A. Yanaka;Songhua Zhang;Masafumi Tauchi;Hideo Suzuki;T. Shibahara;Hirofumi Matsui;Akira Nakahara;N. Tanaka;Masayuki Yamamoto
幽门螺杆菌感染以及NSAID诱导胃粘膜的氧化应激，从而引起粘膜损伤并延缓粘膜修复。细胞可以通过增强抗氧化酶的活性来抵抗慢性氧化应激，从而保护细胞免受DNA损伤。最近的研究清楚地表明，编码Nrf-2（NF-E2 p45-related factor-2）的基因在诱导抗氧化酶对抗氧化应激中起着重要作用。在本文中，我们将描述的细胞机制，其中nrf-2基因刺激抗氧化酶的活动，在暴露于氧化应激。其次，我们还将提到萝卜硫素对胃粘膜的有益作用，萝卜硫素是一种异硫氰酸酯家族，大量存在于西兰花芽中。萝卜硫素刺激nrf-2基因依赖的抗氧化酶活性，从而保护细胞免受氧化损伤。最后，我们将阐述我们对萝卜硫素在H.幽门感染
Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clearly shown that the gene encoding Nrf-2 (NF-E2 p45-related factor-2) plays an important role in the induction of antioxidant enzymes against oxidative stress. In this paper, we will describe the cellular mechanisms by which the nrf-2 gene stimulates anti-oxidant enzyme activities during exposure to oxidative stress. Secondly, we will also mention the beneficial effects of sulforaphane, an isothiocyanate family which is abundantly included in broccoli sprouts, on gastric mucosa. Sulforaphane stimulates nrf-2 gene-dependent anti-oxidant enzyme activities, thereby protecting cells from oxidative injury. Finally, we will state our perspective on the efficacy of sulforaphane in protection and repair of gastric mucosa against oxidative stress during H. pylori infection.