Mortality in schizophrenia
Mortality in schizophrenia
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DOI：
10.1002/pds.1325
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发表时间：
2006-12-01
影响因子：
2.6
通讯作者：
HolmeS, Catriona
中科院分区：
文献类型：
--
作者：
Auquier, Pascal;Lancon, Christophe;HolmeS, Catriona
本文的目的是描述精神分裂症的高死亡率及其致病因素的知识现状，并扩展以前的工作评估方法，可能会降低死亡率。方法对文献数据库Medline和Embase进行计算机检索，检索主题为“死亡率”和“精神分裂症”，并对特别相关的文章进行交叉参考检索，确定1995年以来可用的文献。结果：精神分裂症患者的死亡率是一般人群中预期或观察到的死亡率的两到三倍。造成这种高死亡率的原因是自杀风险增加，特别是年轻男性患者在确诊后不久自杀的风险增加，更重要的是，自然死亡人数增加。为了降低精神分裂症患者的自杀率，大多数研究都集中在确定使患者倾向于尝试或自杀的风险因素，而不健康的生活方式、多种用药和不充分的医疗保健已被证明是导致高自然死亡率的原因。使用抗精神病药物与死亡率之间的联系尚未明确。结论精神分裂症患者死亡率显著增高是事实。现在是时候超越这一主题，并努力采取旨在降低这类患者死亡风险的干预措施。版权所有(c) 2006约翰威利父子有限公司
Purpose The purpose of this article is to describe the current status of knowledge on excess mortality in schizophrenia and its causative factors, and to expand upon previous work evaluating approaches that may reduce mortality rates.Methods Literature available since 1995 was identified in a computerized search of the bibliographical databases Medline and Embase, using the topics 'mortality' and 'schizophrenia', and in a cross-reference search for articles that were particularly relevant.Results Schizophrenia is associated with mortality rates that are two to three times higher than those expected or observed in the general population. This excess of mortality is accounted for by a combination of an increased risk of suicide, in particular in young male patients soon after diagnosis, and more importantly, a higher number of natural deaths. In order to diminish the level of suicide among people with schizophrenia, the majority of research has focused on the identification of risk factors that predispose patients to attempt or commit suicide, while unhealthy styles, polypharmacy and inadequate healthcare have been shown to contribute to the high natural mortality. The link between the use of antipychotics and mortality has not been yet clarified.Conclusion Dramatically increased mortality of schizophrenia patients is well established. It is time to move beyond this topic, and work towards interventions that aim at reducing the mortality risk in such patients. Copyright (c) 2006 John Wiley & Sons, Ltd.