Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls
Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls
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DOI：
10.1007/s10549-009-0693-6
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发表时间：
2010-07-01
影响因子：
3.8
通讯作者：
Jiang, Jun
中科院分区：
文献类型：
--
作者：
Ma, Xiangyu;Qi, Xiaowei;Jiang, Jun
CYP19基因多态与乳腺癌的关系已被广泛报道，但以前的研究结果有些矛盾和不足。为了克服个体研究的局限性，了解真实情况，本研究对3种CYP19基因多态性[R264C多态、CYP19_630 3bP del/ins多态和CYP19_681(TTTA)(N)多态]进行了系统的综述和荟萃分析。共有22项研究，包括10,592例病例和11,720名对照，结果表明，R264C基因多态与总体乳腺癌风险(T与C：OR=1.061，95%CI=0.929-1.212)或基于种族的人群(亚洲人：T与C：OR=1.169，95%CI=1.002-1.363；高加索人：OR=0.787，95%CI=0.597-1.037)无关；同时，在亚洲人群中，3-bpDel/Ins多态与乳腺癌易感性显著相关(等位基因Del与Ins：OR=1.278，95%CI=1.066~1.532)，而等位基因TtTA(12)携带者可显著降低乳腺癌风险(OR=0.752，95%CI=0.603~0.939)。此外，等位基因TTTA(10)携带者与乳腺癌易感性显著相关(OR=1.515，95%CI=1.115~2.058)。结论：潜在功能性的CYP19_630、3bP del/ins多态和CYP19_681(TTTA)(N)多态可能以种族特异性的方式对乳腺癌易感性起低外显性作用。
The association of CYP19 gene polymorphisms with breast cancer has been widely reported, but results of previous studies were somewhat contradictory and underpowered. In order to overcome the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis including three CYP19 gene polymorphisms [R264C polymorphism, CYP19_630 3-bp del/Ins polymorphism, and CYP19_681 (TTTA)(n) polymorphisms]. A total of 22 studies with 10,592 cases and 11,720 controls were identified, and the results showed that R264C polymorphism was not associated with breast cancer risk in overall (T vs. C: OR = 1.061, 95% CI = 0.929-1.212) or race-based populations (T vs. C for Asian: OR = 1.169, 95% CI = 1.002-1.363; for Caucasian: OR = 0.787, 95% CI = 0.597-1.037); meanwhile, for Asian individuals, 3-bpDel/Ins polymorphism showed a significantly association with breast cancer susceptibility (for allele Del vs. allele Ins: OR = 1.278, 95% CI = 1.066-1.532) while the carriers of allele (TTTA)(12) can significantly decrease breast cancer risk (OR = 0.752, 95% CI = 0.603-0.939). Furthermore, the carriers of allele (TTTA)(10) were significantly associated with breast cancer susceptibility (OR = 1.515, 95% CI = 1.115-2.058). It can be concluded that potentially functional CYP19_630 3-bp del/Ins polymorphism and CYP19_681 (TTTA)(n) polymorphisms may play a low penetrance role in breast cancer susceptibility in an ethnicity-specific manner.