Polyaminesas Markers of Responseand Disease Activity in Cancer Chemotherapy1
Polyaminesas Markers of Responseand Disease Activity in Cancer Chemotherapy1
复制标题
癌症化疗中反应和疾病活动的多胺标记1
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
D. Russell
中科院分区：
文献类型：
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作者：
Brian G. M. Dune;S. Salmon;D. Russell
124例血液肿瘤和实体瘤患者在治疗前进行了尿多胺测定。腐胺、亚精胺和精胺与正常人相比均显著增加（p < 0.001）。多胺水平与疾病活动和肿瘤负荷直接相关。在多发性骨髓瘤患者中，腐胺水平与临床疾病活动性以及骨髓浆细胞的体外标记指数显著相关。精脒值反映肿瘤细胞负荷。对56例患者的系列研究表明，尿嘧啶浓度升高两倍以上与细胞杀伤和随后的临床反应高度相关（p < 0.001）。17例患者的血清多胺水平与尿多胺水平相当。我们的数据表明，多胺测定可能在临床上有用，即，基线值作为肿瘤细胞质量和生长分数的指标，并且在治疗过程中增加阿替米嗪作为肿瘤细胞杀伤的优异标志物。
SUMMARY Onehundredtwenty-fourpatientswith hematologicaland solid neoplasmshadpretreatmenturinarypolyaminedeter minations. Putrescine, spermidine, and spermine were all significantly increased as compared to normals (p < 0.001). Polyamine levels were directly related to disease activity and tumor burden. In patientswith multiple myeloma,pu trescine levels were significantly correlated with clinical disease activity as well as the in vitro labeling index of marrow plasma cells. Spermidinevalues reflected tumor cell burden. Serial studies in 56 patients indicated that greaterthantwofold rise in urinaryspermidineduringtreat ment was highly correlated with cell kill and subsequent clinical response (p < 0.001). Serum polyamine levels in 17 patients were found to be comparable to urinary values. Our dataindicatethat polyaminedeterminationscan potentially be clinically useful, i.e., baseline values as indicators of tumor cell mass and growth fraction, and increases in sper midine during treatment as an excellent marker of tumor cell kill.