Distribution of and factors contributing to chronic kidney disease in a middle-aged working population
Distribution of and factors contributing to chronic kidney disease in a middle-aged working population
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DOI：
10.1007/s12199-013-0343-9
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发表时间：
2013-06
影响因子：
4.7
通讯作者：
Y. Noborisaka;M. Ishizaki;Yuichi Yamada;R. Honda;H. Yokoyama;M. Miyao;M. Tabata
中科院分区：
文献类型：
--
作者：
Y. Noborisaka;M. Ishizaki;Yuichi Yamada;R. Honda;H. Yokoyama;M. Miyao;M. Tabata
目的了解日本中年职工慢性肾脏病的分布情况及其发生发展的影响因素。方法采用回顾性研究方法，对2009年至2003年随访的3,964名男性和2,698名女性进行调查，年龄35岁-。结果男性和女性蛋白尿阳性率分别为2.9%和1.1%，CKD总阳性率分别为16.0%和16.1%。中度或重度CKD与心血管疾病和终末期肾病的高危相关[2.0(男性)vs.0.6%(女性)]。55岁男性中有3.3%的人患有高危慢性肾脏病--。体重指数≥30、高血压、糖尿病、吸烟和某些工种与蛋白尿的发生独立相关，而年龄、体重指数、高甘油三酯血症和工种与蛋白尿的发生有关。高危慢性肾脏病的发生与既往轻度慢性肾脏病体征如表皮细胞生长因子减少、蛋白尿、高血压、糖尿病、吸烟、工种有关。结论慢性肾脏病在中年职工中的患病率为16%，男女患病率相当，高危慢性肾脏病多见于男性，其中55-年龄组占3.3%。肥胖、高血压、糖尿病、吸烟及某些工种与慢性肾脏病的发生、发展有关。
ObjectivesTo clarify the distribution of chronic kidney disease (CKD) and the factors contributing to its development and progression in middle-aged Japanese workers/employees.MethodsThis was a retrospective study involving 3,964 men and 2,698 women aged 35–64 years in 2009 who had been followed-up until 2003. Data on proteinuria determined with a dipstick and glomerular filtration rate estimated from serum creatinine concentration (eGFR) were collected in the annual health check-ups.ResultsProteinuria was detected in 2.9 and 1.1 % of the men and women, respectively, and total CKD was detected in 16.0 and 16.1 % of the men and women respectively. Moderate or severe CKD associated a high risk of cardiovascular diseases and end-stage kidney disease was found mostly in the male subjects [2.0 (men) vs. 0.6 % (women)]. High-risk CKD was found in 3.3 % of the men aged 55–64 years. A body mass index (BMI) of ≥30, hypertension, diabetes mellitus (DM), current smoking and some job types were independently related to the development of proteinuria, while age, BMI, hypertriglyceridemia, and job types were related to total CKD. The development of high-risk CKD was related to preceding mild CKD signs of reduced eGFR and proteinuria as well as to hypertension, DM, smoking, and job type.ConclusionsChronic kidney disease was found in 16 % of middle-aged workers with an equal prevalence in both sexes, while high-risk CKD was found mostly in men, of whom 3.3 % were aged 55–64 years. Obesity, hypertension, DM, smoking and some job types were related to the development and progression of CKD.