18FDG‐PET for the assessment of primary head and neck tumors: Clinical, computed tomography, and histopathological correlation in 38 patients
18FDG‐PET for the assessment of primary head and neck tumors: Clinical, computed tomography, and histopathological correlation in 38 patients
复制标题
18FDG-PET 用于评估原发性头颈部肿瘤：38 例患者的临床、计算机断层扫描和组织病理学相关性
DOI：
10.1097/00005537-199810000-00029
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
P. Rigo
中科院分区：
文献类型：
--
作者：
P. Paulus;A. Sambon;D. Vivegnis;R. Hustinx;P. Moreau;J. Collignon;J. Deneufbourg;P. Rigo
目的：评价FDG-PET（氟-2-脱氧葡萄糖-正电子发射断层扫描）在检测头颈部癌症患者淋巴结受累和复发中的临床有用性。研究设计：回顾性审查了38例经活检证实的头颈部癌症患者，这些患者接受了临床、计算机断层扫描（CT）和FDG-PET检查。25例患者在治疗前接受了研究，13例患者接受了疾病复发评估。方法：所有患者均接受手术，并将临床数据、CT和FDG-PET结果与组织病理学结果相关联。结果：25例原发性肿瘤除会厌区1例小的浅表肿瘤外，其余均被检出。组织学检查显示10例患者淋巴结受累; PET检测到5例淋巴结受累。FDG-PET发现1例淋巴结疾病，临床和CT检查未发现。由于病例如此之少，这可能是轶事。观察到5个假阴性结果（显微镜下淋巴结受累）和2个假阳性结果。13例复发性疾病患者中有12例被FDG-PET正确识别。FDG-PET是唯一的成像技术，以确定局部复发的两名患者和淋巴结的参与，在其他两个。1例异物肉芽肿患者出现1个假阳性结果。结论：FDG-PET是一种有用的诊断方法，用于检测复发性肿瘤，并在选定的病例中，精确检测淋巴结受累。进一步研究临床FDG-PET效用的最佳方法是对治疗患者进行随访。关键词：FDG-PET，头颈癌，淋巴结转移，复发性疾病。喉镜，108：1578-1583，1998
Objectives: To evaluate the clinical usefulness of FDG‐PET (fluoro‐2‐deoxy‐glucose‐positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck cancer. Study Design: Retrospective review of 38 patients with biopsy‐proven head and neck cancers who underwent clinical, computed tomography (CT), and FDG‐PET examinations. Twenty‐five patients were studied prior to therapy and 13 patients were evaluated for disease recurrence. Methods: All patients were operated and clinical data, CT, and FDG‐PET results were correlated with histopathological findings. Results: All primary tumors in 25 patients were detected, with the exception of one small superficial localization of the epiglottis. Histopathological examination showed lymph node involvement in 10 patients; PET detected lymph node involvement in five. FDG‐PET found one case of nodal disease not identified by clinical and CT examination. With so few cases, this could be anecdotal. Five false‐negative results (microscopic lymph node involvement) and two false positives were noted. Twelve of 13 patients with recurrent disease were correctly identified with FDG‐PET. FDG‐PET was the only imaging technique to identify local recurrence in two patients and lymph node involvement in two others. One false‐positive result occurred in a patient with a foreign body granuloma. Conclusions: FDG‐PET is a useful diagnostic modality for the detection of recurrent tumors and, in selected cases, precise lymph node involvement. The best way to further investigate the utility of clinical FDG‐PET is in the follow‐up of treated patients. Key Words: FDG‐PET, head and neck cancer, lymph node metastases, recurrent disease. Laryngoscope, 108:1578–1583, 1998