THE THERMAL CONDUCTIVITY OF CORTICAL AND CANCELLOUS BONE
THE THERMAL CONDUCTIVITY OF CORTICAL AND CANCELLOUS BONE
复制标题
DOI：
10.22203/ecm.v035a03
复制
发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Zysset, P.
中科院分区：
文献类型：
--
作者：
Feldmann, A.;Wili, P.;Zysset, P.
靠近脆弱结构（例如神经）的外科干预需要精确地操作外科器械和工具。这些工具不仅会对软组织造成机械损伤，而且还会产生热量，导致骨或软组织热坏死。研究人员和工程师正试图通过实验和模拟来改进这些工具。为了模拟解剖结构中的温度分布，需要可靠的材料常数。因此，本研究旨在研究皮质骨和松质骨的热导率。因此，定制的稳态实验装置的设计和验证。测试了6个牛和3个人皮质骨样本，以及32个具有不同骨体积分数的牛松质骨样本。通过微计算机断层扫描（mu CT）扫描松质骨样本，并创建微有限元（mu FE）体素模型，以迭代计算骨髓的热导率。实验结果为牛皮质骨提供0.64 +/- 0.04 W/mK，为人皮质骨提供0.68 +/- 0.01 W/mK。对于松质骨，热导率与骨体积分数呈线性相关[R平方（R-2）= 0.8096，估计值的标准误差（SEE）= 0.0355 W/mK]。骨髓的热导率估计为0.42 +/- 0.05 W/mK。这些结果将有助于改善人体骨骼的热有限元模拟，并有助于开发新的手术工具或程序。
Surgical interventions close to vulnerable structures, such as nerves, require precise handling of surgical instruments and tools. These tools not only pose the risk of mechanical damage to soft tissues, but they also generate heat, which can lead to thermal necrosis of bone or soft tissues. Researchers and engineers are trying to improve those tools through experimentation and simulations. To simulate temperature distributions in anatomical structures, reliable material constants are needed. Therefore, this study aimed at investigating the thermal conductivity of cortical and cancellous bone. Accordingly, a custom-made steady-state experimental setup was designed and validated. 6 bovine and 3 human cortical bone samples, as well as 32 bovine cancellous bone samples, with variable bone volume fraction were tested. The cancellous bone samples were scanned by micro-computed tomography (mu CT) and micro-finite element (mu FE) voxel models were created to calculate iteratively the thermal conductivity of the bone marrow. The experimental results provided 0.64 +/- 0.04 W/mK for bovine cortical bone and 0.68 +/- 0.01 W/mK for human cortical bone. A linear dependency of thermal conductivity on bone volume fraction was found for cancellous bone [R-square (R-2) = 0.8096, standard error of the estimates (SEE) = 0.0355 W/mK]. The thermal conductivity of the bone marrow was estimated to be 0.42 +/- 0.05 W/mK. These results will help to improve thermal finite element simulations of the human skeleton and aid the development of new surgical tools or procedures.