Increased usage of special educational services by children born to mothers with systemic lupus erythematosus and antiphospholipid antibodies
Increased usage of special educational services by children born to mothers with systemic lupus erythematosus and antiphospholipid antibodies
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DOI：
10.1136/lupus-2014-000034
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发表时间：
2014-04-01
影响因子：
3.9
通讯作者：
Somers, Emily C.
中科院分区：
文献类型：
--
作者：
Marder, Wendy;Romero, Vivian C.;Somers, Emily C.
简介：对患有系统性红斑狼疮（SLE）的母亲所生儿童的长期健康和发育结果的调查表明，这些儿童的学习障碍增加。我们进行了这项观察性研究，探讨母亲自身抗体和抗磷脂抗体综合征（APS）在母亲狼疮患者和神经认知发育之间的关系在他们的后代。通过结构化访谈和病历回顾收集母亲医疗/产科史和儿童围产期/病史的数据。主要结果是需要特殊教育（SE）服务，这是发育迟缓的代表。多元Logistic回归模型被用来检查APS和自身抗体与SE使用之间的关联，占SLE疾病的严重程度和潜在的confronters.Results：数据38母亲和60后代进行了分析：SE服务使用报告为15 60（25%）后代。母亲APS病史与后代SE服务的使用增加显著相关，包括校正狼疮抗凝剂（LA）阳性和潜在混杂因素后（年龄>= 2的延迟OR 5.5-9.4; p
Introduction: Surveys of long-term health and developmental outcomes of children born to mothers with systemic lupus erythematosus (SLE) have suggested an increase in learning disabilities among these children. We performed this observational study to investigate the relationship between maternal autoantibodies and antiphospholipid antibody syndrome (APS) in maternal lupus patients and neurocognitive development among their offspring.Methods: SLE mothers with at least one live birth postlupus diagnosis were enrolled. Data on maternal medical/obstetric history and children's perinatal/medical history were collected by structured interview and medical record reviews. The primary outcome was requirement for special educational (SE) services, a proxy for developmental delays. Multiple logistic regression modelling was used to examine associations between APS and autoantibodies with SE usage, accounting for SLE disease severity and potential confounders.Results: Data on 38 mothers and 60 offspring were analysed: SE service usage was reported for 15 of 60 (25%) offspring. Maternal APS history was significantly associated with increased use of SE services among offspring, including after adjustment for lupus anticoagulant (LA) positivity and potential confounders (OR 5.5-9.4 for delays age >= 2; p