The constructive nature of vision: direct evidence from functional magnetic resonance imaging studies of apparent motion and motion imagery
The constructive nature of vision: direct evidence from functional magnetic resonance imaging studies of apparent motion and motion imagery
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DOI：
10.1046/j.1460-9568.1998.00181.x
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发表时间：
1998-05-01
影响因子：
3.4
通讯作者：
Singer, W
中科院分区：
文献类型：
--
作者：
Goebel, R;Khorram-Sefat, D;Singer, W
回波功能磁共振成像用于监测受试者观看明显运动刺激和进行运动想象时大脑区域的激活变化。人类皮质区域 MT (V5) 和 MST 是“背侧”处理流的第一个区域，与闪烁控制条件相比，其对明显运动刺激的信号强度明显增加。与适当的控制条件相比，由虚幻轮廓定义的图形的表观运动在 V2 和 MT/MST 中引起更大的激活。当受试者仅仅想象几秒钟前看到的移动刺激时，背侧通路的几个区域（V3A、MT/MST、下顶叶和上顶小叶区域）以及前额叶区域（包括 FEF 和 BA 9/46）反应强烈。运动意象过程中的激活随着背侧处理流中距 V1 的区域突触距离的增加而增加。区域 MT/MST 在运动成像期间有选择地激活，但在静态成像控制条件下则不激活。通过客观运动、表观运动和想象运动获得的结果之间的比较，可以进一步深入了解由自下而上和自上而下的神经过程驱动的运动敏感区域的复杂皮层网络。
Echoplanar functional magnetic resonance imaging was used to monitor activation changes of brain areas while subjects viewed apparent motion stimuli and while they were engaged in motion imagery. Human cortical areas MT (V5) and MST were the first areas of the 'dorsal' processing stream which responded with a clear increase in signal intensity to apparent motion stimuli as compared with flickering control conditions. Apparent motion of figures defined by illusory contours evoked greater activation in V2 and MT/MST than appropriate control conditions. Several areas of the dorsal pathway (V3A, MT/MST, areas in the inferior and superior parietal lobule) as well as prefrontal areas including FEF and BA 9/46 responded strongly when subjects merely imagined moving stimuli which they had seen several seconds before. The activation during motion imagery increased with the synaptic distance of an area from V1 along the dorsal processing stream. Area MT/MST was selectively activated during motion imagery but not during a static imagery control condition. The comparison between the results obtained with objective motion, apparent motion and imagined motion provides further insights into a complex cortical network of motion-sensitive areas driven by bottom-up and top-down neural processes.