Prevalence of microorganisms co-infections in human papillomaviruses infected women in Northern China
Prevalence of microorganisms co-infections in human papillomaviruses infected women in Northern China
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我国北方地区人乳头瘤病毒感染女性微生物合并感染情况
DOI：
10.1007/s00404-015-3826-7
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发表时间：
2016-03-01
影响因子：
2.6
通讯作者：
Sun, Zhengrong
中科院分区：
文献类型：
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作者：
Liu, Jianhua;Liu, Weiwei;Sun, Zhengrong
目的由于缺乏关于人乳头瘤病毒（HPV）感染人群生殖器官微生物感染流行情况的数据，本研究旨在评估中国北方地区HPV感染妇女的微生物共感染情况及其相关危险因素。方法收集4290例妇科门诊女性患者的宫颈标本，检测HPV、细菌和酵母菌感染。分析收集的血清样本是否存在人类免疫缺陷病毒（HIV）、乙型肝炎（HBV）、丙型肝炎（HCV）和梅毒螺旋体感染的血清学标志物。采用聚合酶链反应和流式杂交对宫颈刷标本进行HPV分型。沙眼衣原体采用链位移扩增法鉴定，其他微生物采用常规方法检测。评估hpv阳性和阴性患者合并感染的优势比。结果总体而言，hpv感染患者与hpv阴性患者相比，合并感染有风险增加的趋势。在这项对4290名女性门诊患者的横断面研究中，统计分析显示HPV与抗hbv抗体、细菌性阴道病、C。trachomatisandUreaplasma体;HPV感染与抗hiv、抗hcv、T均无相关性。阴道毛滴虫和淋病奈瑟菌，在hpv阳性或阴性患者中仅在少数病例中检测到。结论HPV与HBV、细菌性阴道病、C。trachomatisandU。体。研究结果表明，筛查可能具有协同病理作用的HPV同时存在的不同微生物共感染可能很重要。
PurposeDue to scarce data on the prevalence of genital microorganism infections among individuals with human papillomavirus (HPV) infections, the present study aimed to evaluate microorganism co-infections and associated risk factors in HPV-infected women in Northern China.MethodsCervical samples of 4290 enrolled female patients were collected to detect HPV, bacterial and yeast infections in gynecologic outpatients. Serum samples collected were analyzed for the presence of serological markers for human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV) andTreponema palliduminfections. HPV typing was carried out by polymerase chain reaction and flow-through hybridization on cervical brush specimens.Chlamydia trachomatiswas identified by strand displacement amplification, and other microorganisms were detected by conventional methods. Odds ratio of co-infection was assessed between HPV-positive and -negative patients.ResultsOverall, co-infections among HPV-infected patients showed a trend for risk compared with HPV-negative patients. In this cross-sectional study on 4290 female outpatients, statistical analyses revealed a significant association between HPV and detection of anti-HBV antibodies, bacterial vaginosis,C. trachomatisandUreaplasma urealyticum; no correlation was found between HPV infection and anti-HIV, anti-HCV,T. pallidum, Trichomonas vaginalisandNeisseria gonorrhoeae,which were detected only in few cases among either HPV-positive or -negative patients.ConclusionThe study demonstrated a significant association between HPV and HBV, bacterial vaginosis,C. trachomatisandU. urealyticum. The study results suggest that it may be important to screen for the simultaneous presence of different microorganism co-infections with HPV that may have synergistic pathological effects.