New insights in poly(vinylidene fluoride) (PVDF) membrane hemocompatibility: Synergistic effect of PVDF-g-(acryloyl morpholine) and PVDF-g-(poly(acrylic acid)-argatroban) copolymers
New insights in poly(vinylidene fluoride) (PVDF) membrane hemocompatibility: Synergistic effect of PVDF-g-(acryloyl morpholine) and PVDF-g-(poly(acrylic acid)-argatroban) copolymers
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DOI：
10.1016/j.apsusc.2018.06.231
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发表时间：
2018-11
影响因子：
6.7
通讯作者：
Z. An;Yuanyuan Li;Rui-Song Xu;F. Dai;Yiping Zhao;Li Chen
中科院分区：
文献类型：
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作者：
Z. An;Yuanyuan Li;Rui-Song Xu;F. Dai;Yiping Zhao;Li Chen
亲水性和血液相容性表面设计对于生物应用（尤其是血液透析）中的聚偏二氟乙烯（PVDF）膜至关重要。本工作研究了PVDF-g-(丙烯酰吗啉)(PVDF-g-ACMO)和PVDF-g-(聚(丙烯酸)-阿加曲班)(PVDF-g-(PAA-AG))共聚物共混改性对PVDF膜结构和性能的影响和协同效应。采用浸没相变法制备膜。通过FT-IR和1H NMR对共聚物结构进行了表征。获得的改性膜表面通过 XPS 进行表征。共混改性PVDF中空纤维膜被证实具有优异的亲水性、良好的血液相容性（蛋白质吸附、血小板/红细胞粘附、血浆凝固）、良好的渗透性和抗蛋白质污染性能。随着PVDF-g-ACMO共聚物重量百分比的增加，亲水性和抗溶血性能显着提高，并且PVDF-g-(PAA-AG)共聚物赋予改性膜抗凝血性能。当混合比达到1:3时，混合膜表现出最长的凝血时间（APTT 114.15s和PT 25.65s）。这项工作提供了一种新的修饰方法，以提高 PVDF 膜在潜在生物应用中的血液相容性。
Hydrophilic and hemocompatible surface design is vital for poly(vinylidene fluoride) (PVDF) membranes in biological application especially for hemodialysis. In this work, the influence and synergistic effect of PVDF-g-(acryloyl morpholine) (PVDF-g-ACMO) and PVDF-g-(poly(acrylic acid)-argatroban) (PVDF-g-(PAA-AG)) copolymers blending modification on structure and properties of PVDF membrane were investigated. The membranes were prepared through immersion phase transition method. The copolymer structure was characterized by FT-IR and1H NMR. Modified membrane surfaces obtained were characterized by XPS. The blending modified PVDF hollow fiber membranes were confirmed to have excellent hydrophilicity, good hemocompatibility properties (protein adsorption, platelets/ red blood cells adhesion, plasma coagulation), good permeability and anti-protein fouling performance. The hydrophilic and anti-hemolytic properties were significantly improved with the weight percentage of PVDF-g-ACMO copolymer, and PVDF-g-(PAA-AG) copolymer endow the anti-coagulation of modified membranes. And when the blend ratio was up to 1:3, the blend membranes show the longest clotting time (APTT 114.15 s and PT 25.65 s). This work provides a new modification method to improve the hemocompatibility for PVDF membranes in potential biological applications.