Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
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DOI：
10.1161/01.str.29.6.1177
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发表时间：
1998-06-01
期刊：
影响因子：
8.3
通讯作者：
Miller, BL
中科院分区：
文献类型：
--
作者：
Carmelli, D;DeCarli, C;Miller, BL
背景和目的：MRI检测到的白质高信号（WMH）在老年人中很常见，通常被解释为缺血性脑损伤的亚临床形式。我们用体积MR技术，以探讨贡献的基因和环境的措施，在社区居住的老年男性twin. Methods，脑MR（1.5 T）扫描的样本，从74单卵（MZ）和71双卵（DZ），白色，男性，二战老兵双胞胎出生在美国和年龄68至79岁时扫描。MR定量使用先前发表的半自动分割算法将脑图像分割为全脑、脑脊液（CSF）和WMH体积。双胞胎对协方差计算每个措施，结构方程遗传模型拟合这些data.Results-Total颅，脑实质，CSF，和WMH体积高度相关的MZ对，在MZ对的相关性显着大于DZ对。结构方程模型表明，遗传率分别为91%，92%和73%，总颅，脑实质，和WMH体积。年龄和头部大小的校正使脑实质的遗传率降低到62%（95%置信区间，56%至68%）和WMH体积的遗传力为71%（95%置信区间，66%至76%），大量WMH的先证者一致率在MZ对中为61%，在DZ对中为38%，与患病率为15%，在整个sample. Conclusions，这项研究是第一个量化的相对贡献的遗传和个人环境的影响，以衡量大脑形态在老年人。
Background and Purpose-White matter hyperintensities (WMHs), as detected by MRI, are common among the elderly and are frequently interpreted as representing a subclinical form of ischemic brain damage. We used volumetric MR techniques to investigate the contribution of genes and the environment to measures of brain morphology in a sample of community dwelling elderly male twins.Methods-Brain MR (1.5 T) scans were obtained from 74 monozygotic (MZ) and 71 dizygotic (DZ), white, male, World War II veteran twins born in the United States and age 68 to 79 when scanned. MR quantification used a previously published semiautomated segmentation algorithm to segment brain images into total brain, cerebrospinal fluid (CSF), and WMH volumes. Twin pair covariances were computed for each measure, and structural equation genetic models were fitted to these data.Results-Total cranial, brain parenchyma, CSF, and WMH volumes were highly correlated in MZ pairs, and correlations in MZ pairs were significantly greater than those in DZ pairs. Structural equation modeling indicated heritabilities of 91%, 92%, and 73%, respectively, for total cranial, brain parenchyma, and WMH volumes. Correction for age and head size reduced the heritability of brain parenchyma to 62% (95% confidence interval, 56% to 68%) and the heritability of WMH volume to 71% (95% confidence interval, 66% to 76%),Proband concordance rates for large amounts of WMH were 61% in MZ pairs and 38% in DZ pairs, compared with a prevalence of 15% in the entire sample.Conclusions-This study is the first to quantify the relative contribution of genetic and individual environmental influences to measures of brain morphology in the elderly.