Effects of topiramate on cue-induced cigarette craving and the response to a smoked cigarette in briefly abstinent smokers.
Effects of topiramate on cue-induced cigarette craving and the response to a smoked cigarette in briefly abstinent smokers.
复制标题
托吡酯对提示诱发的香烟渴望的影响以及短暂戒烟者对吸烟的反应。
DOI：
10.1007/s00213-007-0755-6
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发表时间：
2007
影响因子：
3.4
通讯作者：
Flammino,Frank
中科院分区：
文献类型：
--
作者：
Reid,MalcolmS;Palamar,Joseph;Raghavan,Sumithra;Flammino,Frank
临床研究表明，托吡酯，一种抗惊厥药物，可能是有效的戒烟治疗。然而，关于托吡酯对尼古丁戒断和烟瘾的影响及其与吸烟的相互作用知之甚少。ObjectivesThe本研究的目的是调查托吡酯治疗对戒断相关的尼古丁戒断，线索诱导的香烟渴望，以及吸烟的急性影响。材料和方法15名女性和25名男性吸烟者被随机分配接受为期9天的托吡酯治疗（最终滴定剂量，75 mg/天）或安慰剂。在治疗的最后一天，经过3小时的无烟戒烟期后，评估参与者的尼古丁戒断症状，然后进行香烟和中性线索反应性测试。在完成线索暴露测试30分钟后，参与者被评估吸烟的急性影响。提示反应和急性吸烟措施包括主观评级的香烟渴望和戒断和皮肤电导和温度，心率和血压的生理措施。此外，吸烟地形测量使用一个puff体积apparent.ResultsTopiramate治疗增强主观评级后，3小时的禁欲期和减少提示前皮肤电导水平的撤退。香烟线索暴露导致了适度的增加，在渴望，这是不受治疗。托吡酯治疗增强了吸烟的奖励效果，即使参与者吸烟少，每口烟，实现较低的血浆尼古丁level.ConclusionResults表明，托吡酯增强尼古丁戒断和奖励。这些发现质疑托吡酯治疗戒烟的效用。
RationaleClinical studies have shown that topiramate, an anticonvulsant medication, may be effective as a treatment for smoking cessation. However, less is known about topiramate effects on nicotine withdrawal and craving and its interactions with a smoked cigarette.ObjectivesThe objective of this study was to investigate the effects of topiramate treatment on abstinence-related nicotine withdrawal, cue-induced cigarette craving, and the acute effects of a smoked cigarette.Materials and methodsFifteen female and 25 male cigarette smokers were randomly assigned to 9-day treatment with topiramate (final titration dose, 75 mg/day) or placebo. On the last day of treatment, after a 3-h smoke-free abstinence period, participants were evaluated for symptoms of nicotine withdrawal and then underwent cigarette and neutral cue reactivity testing. Thirty minutes after completing cue exposure testing, participants were then evaluated for the acute effects of a smoked cigarette. Cue reactivity and acute smoking measures included subjective ratings of cigarette craving and withdrawal and physiological measures of skin conductance and temperature, heart rate, and blood pressure. In addition, smoking topography was measured using a puff volume apparatus.ResultsTopiramate treatment enhanced subjective ratings of withdrawal after the 3-h abstinence period and reduced pre-cue skin conductance levels. Cigarette cue exposure resulted in a moderate increase in craving, which was unaffected by treatment. Topiramate treatment enhanced the rewarding effects of a smoked cigarette, even while participants smoked less per puff and achieved lower plasma nicotine levels.ConclusionResults suggest that topiramate enhances both nicotine withdrawal and reward. These findings question the utility of topiramate treatment for smoking cessation.