The role of randomization in clinical trials.
The role of randomization in clinical trials.
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DOI：
10.1002/sim.4780010412
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发表时间：
1982-10-01
影响因子：
2
通讯作者：
Armitage, P
中科院分区：
文献类型：
--
作者：
Armitage, P
治疗的随机分配是一般实验设计，特别是临床试验的一个基本特征。它提供了治疗组的广泛可比性，并验证了统计方法用于结果分析的使用。有多种设备可用于改善治疗组间预后因素的平衡。最近一些旨在削弱随机化作用的举措被认为可能具有误导性。在未明确确定治疗选择的情况下，随机化完全符合医学伦理。
Random assignment of treatments is an essential feature of experimental design in general and clinical trials in particular. It provides broad comparability of treatment groups and validates the use of statistical methods for the analysis of results. Various devices are available for improving the balance of prognostic factors across treatment groups. Several recent initiatives to diminish the role of randomization are seen as being potentially misleading. Randomization is entirely compatible with medical ethics in circumstances when the treatment of choice is not clearly identified.