Core genetic module:: The mixed feedback loop -: art. no. 031908
Core genetic module:: The mixed feedback loop -: art. no. 031908
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DOI：
10.1103/physreve.72.031908
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发表时间：
2005-09-01
影响因子：
2.4
通讯作者：
Hakim, V
中科院分区：
文献类型：
--
作者：
François, P;Hakim, V
所谓的混合反馈回路（MFL）是一个小的双基因网络，其中蛋白质a调节蛋白质B的转录，两种蛋白质形成异源二聚体。人们发现，在基因和蛋白质相互作用数据库的统计分析中，它在统计上的代表性过高，并且在几个计算机生成的遗传网络中处于核心位置。在这里，我们提出并数学研究了一个MFL模型，并表明，它本身既可以作为双稳态开关，也可以根据动力学参数作为时钟（振荡器）。给出了MFL相图和非线性振荡状态的详细描述，并讨论了一些生物实例。这些结果强调了蛋白质相互作用在遗传模块功能中的作用，以及明确建模RNA动力学的有用性。
The so-called mixed feedback loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical analyses of gene and protein interaction databases and to lie at the core of several computer-generated genetic networks. Here, we propose and mathematically study a model of the MFL and show that, by itself, it can serve both as a bistable switch and as a clock (an oscillator) depending on kinetic parameters. The MFL phase diagram as well as a detailed description of the nonlinear oscillation regime are presented and some biological examples are discussed. The results emphasize the role of protein interactions in the function of genetic modules and the usefulness of modeling RNA dynamics explicitly.