Central Mechanisms Linking Age-Associated Physiological Changes to Health Span Through the Hypothalamus
Central Mechanisms Linking Age-Associated Physiological Changes to Health Span Through the Hypothalamus
复制标题
通过下丘脑将年龄相关的生理变化与健康跨度联系起来的中心机制
DOI：
10.1007/978-981-16-7977-3_18
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Satoh A
中科院分区：
文献类型：
--
作者：
Teppei Matsumura;Keigo Tomoo;Takeshi Sugimoto;Hayato Tsukamoto;Yasushi Shinohara;Mitsuo Otsuka;Takeshi Hashimoto.;Satoh A
下丘脑位于大脑的腹侧，由几个区域组成，称为核。每个下丘脑核在几个生理特征中发挥不同的作用。越来越多的证据表明，分子/信号通路，包括沉默调节蛋白，雷帕霉素的机械靶点（mTOR），核因子-κB（NF-κB），下丘脑的特定区域（背内侧/外侧下丘脑，内侧基底下丘脑和弓状核），神经干细胞和下丘脑内的温度敏感神经元在调节哺乳动物寿命中发挥作用。这些先前鉴定的分子/通路和下丘脑中的细胞类型在生理特征中具有一些共同的功能。因此，进一步阐明下丘脑通过多种衰老/长寿调节因子控制衰老过程中一种或多种生理特征的共同机制，将有助于我们揭示衰老、长寿和与年龄相关的病理生理学的新的综合机制。
The hypothalamus, which is located on the ventral side of the brain, is composed of several areas, called nuclei. Each hypothalamic nucleus implements a distinct role in several physiological traits. Growing evidence suggest molecules/signaling pathways including sirtuin, mechanistic target of rapamycin (mTOR), and nuclear factor-κB (NF-κB), specific areas of the hypothalamus (the dorsomedial/lateral hypothalamus, mediobasal hypothalamus, and arcuate nucleus), neural stem cells, and temperature-sensitive neurons within the hypothalamus play a role in the regulation of mammalian longevity. These previously identified molecules/pathways and cell types in the hypothalamus have some common function in physiological traits. Therefore, further elucidation of common mechanisms by which the hypothalamus controls one or more physiological traits during aging through multiple aging/longevity regulators will help us to uncover novel integrative mechanisms underlying aging, longevity, and age-associated pathophysiology.