Biomarkers enable prediction of tacrolimus resistance in patients with severe allergic conjunctivitis
Biomarkers enable prediction of tacrolimus resistance in patients with severe allergic conjunctivitis
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生物标志物可以预测严重过敏性结膜炎患者的他克莫司耐药性
DOI：
10.1111/all.15535
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发表时间：
2022
期刊：
影响因子：
12.4
通讯作者：
Fujishima Hiroshi
中科院分区：
文献类型：
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作者：
Okada Naoko;Yazu Hiroyuki;Shimizu Eisuke;Fukagawa Kazumi;Nunomura Satoshi;Saito Hirohisa;Matsumoto Kenji;Kawaguchi Atsushi;Izuhara Kenji;Fujishima Hiroshi
CCL 17、TARC/胸腺和活化调节趋化因子。然后，我们发现了另一种更简单的方法，用于通过使用3个参数的树分析来预测对他克莫司的抗性/响应性：骨膜蛋白、CCL 17和年龄（图2B）。缩写AKC特应性角结膜炎CCL 17胸腺和活化调节趋化因子/TARC PCA主成分分析ROC受试者工作特征VKC春季角结膜炎重度过敏性结膜炎、春季角结膜炎（VKC）和特应性角结膜炎（AKC），具有异质性和复杂的免疫学特征。[[1]局部钙调神经磷酸酶抑制剂，如他克莫司和环孢素A，仅在一些国家临床上可用，不仅有效控制症状，而且有效减少联合给药类固醇引起的严重不良反应。[[4]]然而，大约30%的局部他克莫司治疗的患者显示出一过性或永久性耐药。[5]我们之前证明了骨膜蛋白（一种众所周知的过敏性炎症介质）在过敏性结膜炎患者的泪液中升高，[6]但泪液骨膜蛋白与他克莫司治疗抵抗之间的相关性尚不清楚。[摘自文章]过敏的版权是威利-布莱克威尔的财产，其内容不得复制或通过电子邮件发送到多个网站或张贴到一个列表服务器未经版权保持器的明确书面许可。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
CCL17, TARC/thymus and activation-regulated chemokine. gl We then found another, simpler way for predicting resistance/responsiveness to tacrolimus by tree analysis using 3 parameters: periostin, CCL17, and age (Figure 2B). Abbreviations AKC atopic keratoconjunctivitis CCL17 thymus and activation-regulated chemokine/TARC PCA principal component analysis ROC receiver operating characteristic VKC vernal keratoconjunctivitis Severe allergic conjunctivitis, vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC), has heterogeneous and complicated immunological characteristics.[[1],[3]] Topical calcineurin inhibitors, such as tacrolimus and cyclosporine A, which are clinically available only in some countries, are effective not only in controlling the symptoms, but also in reducing serious adverse effects caused by co-administered steroids.[[4]] However, approximately 30% of patients treated with topical tacrolimus show transient or permanent resistance.[5] We previously demonstrated that periostin, a well-known mediator of allergic inflammation, is elevated in tears from allergic conjunctivitis patients,[6] but the correlation between tear periostin and resistance to tacrolimus treatment is unknown.[Extracted from the article]Copyright of Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.
影响因子：
1.7
作者：
Al Hanaineh, Abeer T.;Hassanein, Dina H.;El Zawahry, Omar M.
通讯作者：
El Zawahry, Omar M.