Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF-β and MMP9
Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF-β and MMP9
复制标题
DOI：
10.1155/2019/7028314
复制
发表时间：
2019-09-24
影响因子：
--
通讯作者：
Salama, Rania A. A.
中科院分区：
文献类型：
--
作者：
El-Baz, Farouk K.;Salama, Abeer;Salama, Rania A. A.
肝纤维化是一个严重的全球卫生保健问题，是许多慢性肝病、肝硬化、肝炎和毒素积累的结果。本研究旨在探讨盐杜氏藻对硫代乙酰胺（TAA-）致大鼠肝纤维化的抗纤维化疗效。TAA （200mg/kg, ig）每周2次，连续6周诱导肝纤维化。TAA后4周，每日口服（100、200 mg/kg）海苔草，每日口服（100 mg/kg）水飞蓟素。评估血清转氨酶活性、肝脏炎症细胞因子、纤维化生物标志物和肝脏组织病理学。TAA显著(p
Liver fibrosis represents a serious global health-care problem and is the outcome of many chronic liver diseases, cirrhosis, hepatitis, and toxin accumulation. The present study aimed to evaluate the antifibrotic curative effect of Dunaliella salina (D. salina) on thioacetamide- (TAA-) induced liver fibrosis in rats. Liver fibrosis was induced by TAA (200mg/kg; i.p.) twice per week for 6 weeks. D. salina was given orally (100 and 200 mg/kg) and silymarin was given orally (100 mg/kg) daily, for 4 weeks after TAA. Serum transaminase activities, liver inflammatory cytokines, fibrotic biomarkers, and liver histopathology were assessed. TAA significantly (p