ANGIOTENSIN CONVERTING ENZYME-INHIBITION PREVENTS DEVELOPMENT OF MUSCLE AND NERVE DYSFUNCTION AND STIMULATES ANGIOGENESIS IN STREPTOZOTOCIN-DIABETIC RATS
ANGIOTENSIN CONVERTING ENZYME-INHIBITION PREVENTS DEVELOPMENT OF MUSCLE AND NERVE DYSFUNCTION AND STIMULATES ANGIOGENESIS IN STREPTOZOTOCIN-DIABETIC RATS
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DOI：
10.1007/bf00400846
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发表时间：
1992-01-01
期刊：
影响因子：
8.2
通讯作者：
ROBERTSON, S
中科院分区：
文献类型：
--
作者：
CAMERON, NE;COTTER, MA;ROBERTSON, S
观察血管紧张素转换酶抑制剂赖诺普利对链脲佐菌素糖尿病大鼠慢、快肌收缩特性、神经传导和抗缺氧能力以及肌肉和神经毛细血管密度的影响。治疗可部分防止比目鱼肌收缩舒张延长（p < 0.01）。22%的快速抽动指长伸肌强直张力产生缺陷也得到改善（p < 0.01）。糖尿病患者坐骨神经运动和感觉传导速度分别降低25%和12%，赖诺普利组恢复正常75% （p < 0.01）。糖尿病患者对缺氧传导阻滞的抵抗增加47% （p < 0.01）。赖诺普利治疗后缺氧耐受性正常。糖尿病对神经和肌肉的毛细血管化影响较小；赖诺普利可使坐骨神经毛细血管密度增加17%，使指长伸肌毛细血管密度增加40% （p < 0.01）。对于比目鱼，较小的治疗引起的毛细血管密度增加导致毛细血管/肌纤维比升高（p < 0.01）。这些结果提示赖诺普利促进血管生成。由此得出结论，预防性赖诺普利治疗的有益作用可能取决于周围血管阻力的降低和组织血流量的改善，这表明相对缺氧是实验性糖尿病肌病和神经病变发展的重要因素。
The effects of the angiotensin converting enzyme inhibitor lisinopril on slow and fast twitch muscle contractile properties, nerve conduction and hypoxic resistance, and muscle and nerve capillary density were examined in streptozotocin-diabetic rats. Prolongation of soleus contraction and relaxation were partially prevented by treatment (p < 0.01). A 22% deficit in fast twitch extensor digitorum longus tetanic tension production was also ameliorated (p < 0.01). Sciatic motor and sensory conduction velocity, 25% and 12% reduced by diabetes respectively, were 75% normalized by lisinopril (p < 0.01). There was a 47% increase in resistance to hypoxic conduction block with diabetes (p < 0.01). Lisinopril treatment resulted in normal hypoxic resistance. Capillarisation of nerve and muscle was little affected by diabetes; however, there was a 17% increase in capillary density in sciatic nerve, and a 40% increase in extensor digitorum longus muscle with lisinopril (p < 0.01). For soleus, a smaller treatment-induced increase in capillary density led to an elevated capillary/muscle fibre ratio (p < 0.01). These results suggest that lisinopril promoted angiogenesis. It was concluded that the beneficial effect of preventive lisinopril treatment is likely to depend upon a reduction of peripheral vascular resistance and improvement of tissue blood flow, which implicates relative hypoxia as an important factor in the development of myopathy and neuropathy in experimental diabetes.