On-road exposure to highway aerosols.: 2.: Exposures of aged, compromised rats
On-road exposure to highway aerosols.: 2.: Exposures of aged, compromised rats
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DOI：
10.1080/08958370490443222
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发表时间：
2004-01-01
影响因子：
2.1
通讯作者：
Oberdörster, G
中科院分区：
文献类型：
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作者：
Elder, A;Gelein, R;Oberdörster, G
在对患有心肺疾病的老年人的流行病学研究中，环境颗粒物污染与不良健康影响有关。我们推测，超细颗粒（UFP）有助于这些影响，特别是当它们是新鲜产生的，并发生在高数量的浓度。已经使用实验室生成的替代物、固定发动机的稀释排气或浓缩的环境UFP进行了确定不利影响的研究。这种实验存在方法上的困难，并且这些颗粒对环境空气中发现的颗粒的模拟效果如何仍然存在问题。新产生的UFP在高速公路上的浓度很高，车辆乘客直接接触到它们。我们希望将大鼠暴露于这些UFP中，以测试它们产生影响的潜力。由于这种暴露以前没有做过，我们的研究的一个目的是证明道路暴露研究的可行性。其次，我们希望确定在年老、受损的大鼠中是否存在显著的应激相关效应。老年大鼠（21个月的F-344）直接暴露在高速公路上的气溶胶（
Ambient particulate pollution is associated with adverse health effects in epidemiological studies of the elderly with cardiopulmonary diseases. We hypothesize that ultrafine particles (UFP) contribute to these effects, especially when they are freshly generated and occur at high number concentrations. Studies to determine adverse effects have been performed using laboratory-generated surrogates, diluted exhaust from stationary engines, or concentrated ambient UFPs. Methodological difficulties exist with such experiments, and questions remain about how well these particles model those found in ambient air. Freshly generated UFPs are present at high concentrations on highways and vehicle passengers are directly exposed to them. We wished to expose rats to these UFPs to test their potential to cause effects. Since such exposures have not been done before, one objective of our study was to demonstrate the feasibility of an on-road exposure study. Secondly, we wished to determine if there are significant exposure-related effects in aged, compromised rats. Old rats (21-mo F-344) were exposed directly on highways to either the aerosol (