Hypothyroidism.
Hypothyroidism.
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DOI：
10.1016/s0140-6736(17)30703-1
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发表时间：
2017-09-23
期刊：
影响因子：
--
通讯作者：
Peeters RP
中科院分区：
文献类型：
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作者：
Chaker L;Bianco AC;Jonklaas J;Peeters RP
甲状腺功能减退症是甲状腺激素缺乏症的一种常见病症，很容易诊断和治疗，但如果不治疗，严重病例可能致命。甲状腺功能减退症的定义是基于相关生化参数的统计参考范围，并且越来越成为一个争论的问题。甲状腺功能减退症的临床表现范围从危及生命到没有体征或症状。成人最常见的症状是疲劳，嗜睡，耐寒，体重增加，便秘，声音变化和皮肤干燥，但临床表现可能因年龄和性别而异。标准治疗是甲状腺激素替代疗法与左旋甲状腺素。然而，达到生化治疗目标的患者中有相当一部分有持续的投诉。在本次研讨会中，我们讨论了甲状腺功能减退症的流行病学、病因和症状;总结了诊断、长期风险、治疗和管理的证据;并强调了未来的研究方向。
Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors. The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. In this Seminar, we discuss the epidemiology, causes, and symptoms of hypothyroidism; summarise evidence on diagnosis, long-term risk, treatment, and management; and highlight future directions for research.