First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles
First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles
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DOI：
10.1016/j.tetlet.2008.02.130
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发表时间：
2008-04-14
影响因子：
1.8
通讯作者：
Djakovitch, Laurent
中科院分区：
文献类型：
--
作者：
Cusati, Giuseppe;Djakovitch, Laurent
报道了一种用于吲哚选择性 C3-芳基化的简单非均相钯催化程序。在相对标准的反应条件下（Pd-催化剂、K(2)CO(3)、二恶烷、回流），仅使用 1 mol% [Pd(NH(3))(4)]/NaY 作为催化剂，2 位取代或未取代的吲哚达到预期的 C3-芳基化吲哚的 92% 转化率（即 85% 分离产率）。 (c) 2008 Elsevier Ltd. 保留所有权利。
A simple heterogeneously palladium-catalysed procedure for the selective C3-arylation of indoles is reported. Under relatively standard reaction conditions (Pd-catalyst, K(2)CO(3), dioxane, reflux), using only 1 mol % [Pd(NH(3))(4)]/NaY as the catalyst, indoles substituted or not at position 2 gave up to 92% conversion (i.e., 85% isolated yield) towards the expected C3-arylated indole. (c) 2008 Elsevier Ltd. All rights reserved.