Sonic Hedgehog stimulates migration of MCF-7 breast cancer cells through Rac1
Sonic Hedgehog stimulates migration of MCF-7 breast cancer cells through Rac1
复制标题
Sonic Hedgehog 通过 Rac1 刺激 MCF-7 乳腺癌细胞迁移
DOI：
10.7555/jbr.32.20180100
复制
发表时间：
2019-09
影响因子：
2.3
通讯作者：
Steven Y Cheng
中科院分区：
文献类型：
--
作者：
Tian Shen;Bo’ang Han;Yan Leng;Sen Yan;Junfeng Shi;Shen Yue;Steven Y Cheng
乳腺癌作为女性最常见的肿瘤之一，近年来引起了研究者和临床医生的极大兴趣。尽管早期诊断和最佳治疗方案，恶性或转移性乳腺癌患者的预后仍然不容乐观。Hedgehog信号通路是胚胎发育过程中不可缺少的经典通路，参与多种肿瘤的生长。在本研究中，研究了Sonic Hedgehog（Shh）对乳腺癌细胞的作用。我们确定Shh信号刺激MCF-7乳腺癌细胞的迁移。Smo和Gli 1参与了Shh刺激的MCF-7细胞迁移。激活Smo和Gli 1诱导细胞迁移，这被其特异性拮抗剂阻断。Shh信号对MCF-7细胞的作用不依赖于Wnt 5a、Dvl 2和Rab 35，而直接依赖于Rac 1。总之，我们的研究表明，Shh促进乳腺癌细胞迁移通过Rac 1独立的非经典Wnt信号通路，这可能是一个合理的分子靶点，联合药物治疗乳腺癌。
As one of the most common tumors in women, breast cancer has drawn considerable interest from investigators and clinicians in recent years. Despite early diagnosis and best therapeutic regimens available, the prognosis of malignant or metastatic breast cancer patients is still not optimistic. Hedgehog signaling, a classical pathway indispensable to embryonic development, participates in the growth of a variety of tumors. In the present study, the effect of Sonic Hedgehog (Shh) on breast cancer cells was investigated. We identified that Shh signal stimulated the migration of MCF-7 breast cancer cells. Smo and Gli1 were involved in Shh-stimulated migration of MCF-7 cells. Activating Smo and Gli1 induced cell migration, which was blocked by their specific antagonists. The effect of Shh signaling on MCF-7 cells was independent of Wnt5a, Dvl2 and Rab35, but directly dependent on Rac1. In conclusion, our study suggested that Shh promotes breast cancer cell migration via Rac1 independently of the non-canonical Wnt signaling pathway, which may represent a rational molecular target for combination medication in breast cancer.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.7
作者：
El-Zaatari M;Kao JY;Tessier A;Bai L;Hayes MM;Fontaine C;Eaton KA;Merchant JL
通讯作者：
Merchant JL
刺猬信号转导：主要参与者，致癌驱动因素和癌症治疗。
影响因子：
11.8
作者：
Pak, Ekaterina;Segal, Rosalind A.
通讯作者：
Segal, Rosalind A.
影响因子：
9.2
作者：
McDermott, Kimberly M.;Liu, Bob Y.;Tisty, Thea D.;Pazour, Gregory J.
通讯作者：
Pazour, Gregory J.
影响因子：
--
作者：
Benvenuto M;Masuelli L;De Smaele E;Fantini M;Mattera R;Cucchi D;Bonanno E;Di Stefano E;Frajese GV;Orlandi A;Screpanti I;Gulino A;Modesti A;Bei R
通讯作者：
Bei R