Ruthenium-Catalyzed Regioselective Reactions of Nitriles and 1,3-Dicarbonyl Compounds with Terminal Alkynes
Ruthenium-Catalyzed Regioselective Reactions of Nitriles and 1,3-Dicarbonyl Compounds with Terminal Alkynes
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DOI：
10.1055/s-0029-1218373
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发表时间：
2009-12-01
期刊：
影响因子：
2
通讯作者：
Nakano, Yoshinori
中科院分区：
文献类型：
--
作者：
Murahashi, Shun-Ichi;Naota, Takeshi;Nakano, Yoshinori
RuH_2（PPh_3）（4）催化的腈与端炔的反应在中性条件下高效地进行，得到相应的Michael加成物。此外，在中性条件下，1，3-二羰基化合物与α-位的末端炔反应，以高的区域选择性得到外亚甲基化合物。区域选择性取决于底物的变化。提出了精确的机理。
RuH2(PPh3)(4)-catalyzed reaction of nitriles with terminal alkynes proceeds highly efficiently under neutral conditions to give the corresponding Michael adducts. Furthermore, 1,3-dicarbonyl compounds react with terminal alkynes at the alpha-position to afford the exo-methylene compounds with high regioselectivity under neutral conditions. The regioselectivity depends upon the change of substrates. The precise mechanism is presented.