Targeting Dysbiosis for the Treatment of Liver Disease.
Targeting Dysbiosis for the Treatment of Liver Disease.
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DOI：
10.1055/s-0035-1571276
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发表时间：
2016-02
影响因子：
4.2
通讯作者：
Loomba R
中科院分区：
文献类型：
--
作者：
Anand G;Zarrinpar A;Loomba R
肠道微生物群由胃肠道中的大量微生物组成，这些微生物有利于宿主的新陈代谢，帮助消化，并有助于正常的免疫功能。微生物组成的改变会导致肠道生物失调，这与几种疾病有关，包括肥胖、炎症性肠病和肝病。在过去的几年里，人们发现了肠道微生物区系与肝脏之间的重要相互作用，发现了肝病发生和发展的可能机制，并有望通过治疗来预防或阻止肝病的进展。在这篇综述中，作者研究了非酒精性肝病、酒精性肝病和肝硬变中非酒精性肝病所致肝病的机制，重点介绍了目前有关非酒精性肝病、酒精性肝病和肝硬变的相关知识，并讨论了潜在的治疗靶点。
The gut microbiome is composed of a vast number of microbes in the gastrointestinal tract, which benefit host metabolism, aid in digestion, and contribute to normal immune function. Alterations in microbial composition can result in intestinal dysbiosis, which has been implicated in several diseases including obesity, inflammatory bowel disease, and liver diseases. Over the past several years, significant interactions between the intestinal microbiota and liver have been discovered, with possible mechanisms for the development as well as progression of liver disease and promising therapeutic targets to either prevent or halt the progression of liver disease. In this review the authors examine mechanisms of dysbiosis-induced liver disease; highlight current knowledge regarding the role of dysbiosis in nonalcoholic liver disease, alcoholic liver disease, and cirrhosis; and discuss potential therapeutic targets.
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影响因子：
29.4
作者：
Chen P;Torralba M;Tan J;Embree M;Zengler K;Stärkel P;van Pijkeren JP;DePew J;Loomba R;Ho SB;Bajaj JS;Mutlu EA;Keshavarzian A;Tsukamoto H;Nelson KE;Fouts DE;Schnabl B
通讯作者：
Schnabl B
影响因子：
3.7
作者：
Bajaj JS;Heuman DM;Sanyal AJ;Hylemon PB;Sterling RK;Stravitz RT;Fuchs M;Ridlon JM;Daita K;Monteith P;Noble NA;White MB;Fisher A;Sikaroodi M;Rangwala H;Gillevet PM
通讯作者：
Gillevet PM
影响因子：
9.8
作者：
Bauer, TM;Steinbrückner, B;Blum, HE
通讯作者：
Blum, HE
影响因子：
29.4
作者：
Dhiman, Radha K.;Rana, Baldev;Chawla, Yogesh K.
通讯作者：
Chawla, Yogesh K.
影响因子：
158.5
作者：
Bass, Nathan M.;Mullen, Kevin D.;Forbes, William P.
通讯作者：
Forbes, William P.