Association of gestational diabetes mellitus and low-density lipoprotein (LDL) particle size
Association of gestational diabetes mellitus and low-density lipoprotein (LDL) particle size
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DOI：
10.33549/physiolres.931073
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Williams, M. A.
中科院分区：
文献类型：
--
作者：
Qiu, C.;Rudra, C.;Williams, M. A.
小而密的低密度脂蛋白（LDL）占优势是2型糖尿病血脂异常状态的特征。然而，没有研究调查妊娠期糖尿病（GDM），这是2型糖尿病的病理生理相似的关联。我们假设GDM患者的LDL颗粒大小较对照组减小。采用梯度凝胶电泳法对105例GDM患者和96例对照者非空腹分娩期血浆中LDL亚类表型进行了分析。所有参与者都没有预先存在的糖尿病或高血压。作者使用逻辑回归估计比值比（OR）和95%置信区间（CI），调整混杂因素。与具有大、浮力表型的女性相比，具有该表型的女性患GDM的风险显着增加4.9倍（95%CI：1.1-23.2）。当模型中包括血浆甘油三酯和其他混杂因素时，这种关联的程度减弱（OR= 4.2，95%CI：0.5-39.5）。GDM患者的平均LDL颗粒大小小于对照组（270.1 vs. 272.7埃，p=0.003）。LDL颗粒每减少10埃，GDM风险的OR为1.8（95%CI：0.9-3.3）.需要进行大规模的前瞻性研究来评估妊娠早期较小的LDL颗粒与随后GDM风险之间的关系。
A predominance of small, dense low-density lipoproteins (LDL) is characteristic of the dyslipidemic state seen in type 2 diabetes. However, no study has investigated the association in gestational diabetes mellitus (GDM), which is pathophysiologically similar to type 2 diabetes. We hypothesized that LDL particle size is reduced in GDM cases compared with controls. Gradient gel electrophoresis was used to characterize LDL subclass phenotypes in non-fasting intrapartum plasma from 105 GDM cases and 96 controls. All participants were free of pre-existing diabetes or hypertension. The authors used logistic regression to estimate odds ratios (OR) and 95 % confidence intervals (CI) adjusted for confounders. Women with this phenotype had a significant 4.9-fold (95 % CI: 1.1-23.2) increased risk of GDM compared with those with the large, buoyant phenotype. The magnitude of this association was attenuated when plasma triglyceride and other confounders were included in the model (OR= 4.2, 95 % CI: 0.5-39.5). Mean LDL particle size in GDM cases was smaller compared with controls (270.1 vs. 272.7 angstrom, p=0.003). The OR of GDM risk was 1.8 (95 % CI: 0.9-3.3) for every 10-angstrom reduction in LDL particle size. Large prospective studies are needed to evaluate the association between smaller LDL particle size in early pregnancy with subsequent GDM risk.