Separation from a bonded partner alters neural response to inflammatory pain in monogamous rodents
Separation from a bonded partner alters neural response to inflammatory pain in monogamous rodents
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DOI：
10.1016/j.bbr.2021.113650
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发表时间：
2021-11
影响因子：
2.7
通讯作者：
Takahiro Okuda;Y. Osako;C. Hidaka;Makoto Nishihara;L. Young;Shinichi Mitsui;K. Yuri
中科院分区：
文献类型：
--
作者：
Takahiro Okuda;Y. Osako;C. Hidaka;Makoto Nishihara;L. Young;Shinichi Mitsui;K. Yuri
疼痛的经验是已知的社会因素的修改，但大脑机制仍然不明。我们最近建立了一个动物模型的社会压力诱导的痛觉过敏（SSIH）使用社会一夫一妻制的啮齿动物，草原田鼠，其中男性与他们的女性合作伙伴（损失男性）分离变得焦虑，并显示加剧炎症疼痛行为相比，男性与合作伙伴（配对男性）。在本研究中，探索神经通路参与SSIH，疼痛相关的大脑区域，或“疼痛矩阵”，在炎症性疼痛配对和损失之间的神经元激活的差异检测使用Fos免疫反应（Fos-ir）。男性与女性配对，并使用伴侣偏好测试在所有受试者中确认配对关系。在福尔马林诱导的炎性疼痛，配对和损失的男性表现出显着的诱导Fos-ir在整个分析的疼痛基质成分相比，基础条件（无注射），并没有组间差异的免疫反应性注射的男性在许多脑区。然而，损失的男性有显着较低的Fos-IR炎症疼痛后，内侧前额叶皮层和核壳比配对的男性，即使基础Fos-IR水平组之间是可比的。值得注意的是，这两个具有不同Fos-ir的区域是多巴胺和催产素系统的主要组成部分，它们在配对和疼痛调节中起着关键作用。目前的研究结果表明，疼痛加剧的社会压力出现的可能性，通过改变信号在社会脑回路。
Pain experience is known to be modified by social factors, but the brain mechanisms remain unspecified. We recently established an animal model of social stress-induced hyperalgesia (SSIH) using a socially monogamous rodent, the prairie vole, in which males separated from their female partners (loss males) became anxious and displayed exacerbated inflammatory pain behaviors compared to males with partners (paired males). In the present study, to explore the neural pathways involved in SSIH, a difference in neuronal activation in pain-related brain regions, or "pain matrix", during inflammatory pain between paired and loss males was detected using Fos immunoreactivity (Fos-ir). Males were paired with a female and pair bonding was confirmed in all subjects using a partner preference test. During formalin-induced inflammatory pain, both paired and loss males showed a significant induction of Fos-ir throughout the analyzed pain matrix components compared to basal condition (without injection), and no group differences in immunoreactivity were found among the injected males in many brain regions. However, the loss males had significantly lower Fos-ir following inflammatory pain in the medial prefrontal cortex and nucleus accumbens shell than the paired males, even though base Fos-ir levels were comparable between groups. Notably, both regions with different Fos-ir are major components of the dopamine and oxytocin systems, which play critical roles in both pair bonding and pain regulation. The present results suggest the possibility that pain exacerbation by social stress emerges through alteration of signaling in social brain circuitry.