Immunogenicity of varying dosages of 7-valent pneurnococcal polysaccharide-protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine
Immunogenicity of varying dosages of 7-valent pneurnococcal polysaccharide-protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine
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DOI：
10.1016/j.vaccine.2007.02.062
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发表时间：
2007-05-16
期刊：
影响因子：
5.5
通讯作者：
Carlone, George M.
中科院分区：
文献类型：
--
作者：
Jackson, Lisa A.;Neuzil, Kathleen M.;Carlone, George M.
在这项剂量范围的研究中，220名在登记前至少5年接种了23价肺炎球菌多糖(PNPs)疫苗的老年人被分配接受四卷(0.1、0.5、1或2毫升)7价肺炎球菌结合物(PNC)疫苗中的一种或0.5毫升剂量的23价PNPs疫苗。所有参与者在登记后一年接受了减少的0.1mlPUPS疫苗的挑战剂量。有证据表明PNC疫苗有剂量反应，1mlPNC组的抗体水平明显高于PNPs组。没有观察到对挑战疫苗接种的加强反应。在老年人中，接种1毫升的PNC疫苗比接种0.5毫升的PNPs疫苗更具免疫原性。(C)2007爱思唯尔有限公司。保留所有权利。
In this dose-ranging study 220 seniors who had received the 23-valent pneumococcal polysaccharide (PnPS) vaccine at least 5 years prior to enrollment were assigned to receive one of four volumes (0.1, 0.5, 1 or 2 ml) of 7-valent pneumococcal conjugate (PnC) vaccine or a 0.5 ml dose of 23-valent PnPS vaccine. All participants received a reduced challenge dose of 0.1 ml of Pups vaccine I year after enrollment. There was evidence of a dose response to PnC vaccine and antibody levels in the I ml PnC group tended to be significantly higher than in the PnPS group. A booster response to the challenge vaccination was not observed. Administration of a 1 ml dose of PnC vaccine is more immunogenic than 0.5 ml of PnPS vaccine in elderly adults previously vaccinated with pups vaccine. (C) 2007 Elsevier Ltd. All rights reserved.