Effect of meal timing on postprandial glucose responses to a low glycemic index meal: A crossover trial in healthy volunteers
Effect of meal timing on postprandial glucose responses to a low glycemic index meal: A crossover trial in healthy volunteers
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DOI：
10.1016/j.clnu.2017.11.010
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发表时间：
2019-02-01
影响因子：
6.3
通讯作者：
Bonham, Maxine P.
中科院分区：
文献类型：
--
作者：
Leung, Gloria K. W.;Huggins, Catherine E.;Bonham, Maxine P.
背景与目的：葡萄糖代谢在一定程度上受昼夜节律的调节。与早晨相比，夜间餐后血糖反应被夸大，胰岛素敏感性降低。持续的低糖耐量可能与轮班工人患2型糖尿病和心血管疾病的风险增加有关。膳食类型的操纵可能能够抑制这种餐后波动。因此，本研究的目的是调查餐后葡萄糖和胰岛素的反应，以低血糖指数（GI）餐在早上相比，在晚上的健康volunteers.Methods：口服葡萄糖耐量试验（OGTT），进行确认昼夜葡萄糖反应。参与者在0800 h（早晨）和2000 h（晚上）摄入葡萄糖溶液。在另一项试验中，参与者在0800 h、2000 h和0000 h（午夜）摄入低GI餐（3.3 MJ，48%能量（E）来自碳水化合物，40%E来自脂肪，11%E来自蛋白质，22 g纤维）。在3小时内收集餐后血糖和胰岛素。计算曲线下的增量面积（iAUC），并使用Wilcoxon符号秩检验显著性。p值
Background & aims: Glucose metabolism is, in part, regulated by the circadian rhythm. Postprandial glucose response is exaggerated and insulin sensitivity is reduced at night compared with the morning. Sustained poor glucose tolerance may be related to the increased risk of type-2 diabetes mellitus and cardiovascular disease experienced by shift workers. Manipulation of meal type may be able to dampen such postprandial excursions. Therefore, the study's aim was to investigate postprandial glucose and insulin responses to a low glycemic index (GI) meal in the morning compared to night in healthy volunteers.Methods: An oral glucose tolerance test (OGTT), was undertaken to confirm diurnal glucose response. Participants consumed a glucose solution at 0800h (morning) and 2000h (evening). In a separate trial, participants consumed a low GI meal (3.3 MJ, 48% energy (E) from carbohydrate, 40%E from fat and 11%E from protein, 22 g fiber) at 0800h, 2000h and 0000h (midnight). Postprandial glucose and insulin were collected over 3 h. Incremental area under the curve (iAUC) was calculated and significance tested using Wilcoxon-signed rank. A p-value