STUDIES ON AGEING IN NEMATODES III. ELECTRONMICROSCOPICAL STUDIES ON AGE-ASSOCIATED CELLULAR DAMAGE
STUDIES ON AGEING IN NEMATODES III. ELECTRONMICROSCOPICAL STUDIES ON AGE-ASSOCIATED CELLULAR DAMAGE
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DOI：
10.1016/0047-6374(72)90091-7
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发表时间：
1972-01-01
影响因子：
5.3
通讯作者：
Gershon, D.
中科院分区：
文献类型：
--
作者：
Epstein, J.;Himmelhoch, S.;Gershon, D.
自由生活的briggsae线虫被用作衰老现象研究的模型。电镜观察不同年龄动物的横截面，发现老年性布氏隐杆线虫某些组织损伤严重。在衰老动物的肠上皮中证实了含有酸性磷酸酶活性的色素颗粒的进行性年龄依赖性积累。这些颗粒可能是老化色素，是细胞成分过氧化的产物。这些色素颗粒最终占据大部分细胞质体积，似乎导致整个组织的破坏。在动物生命的末期，可以观察到对身体肌肉细胞和神经复合体的广泛损害。
The free-living nematode Caenorhabditis briggsae was used as a model for the study of the phenomenon of ageing. Electronmicroscopical examination of cross sections through animals of different ages revealed severe damage to certain tissues of aged Caenorhabditis briggsae. Progressive age-dependent accumulation of pigment granules containing acid phosphatase activity was demonstrated in the intestinal epithelium of ageing animals. It is suggested that these granules are age-pigment which is the product of peroxidation of cellular constituents. These pigment granules eventually occupy most of the cytoplasmic volume and appear to lead to the breakdown of the entire tissue. At the terminal period of the animal's life, extensive damage to body muscle cells and nerve complexes is observed.