LOW INCIDENCE OF IGA NEPHROPATHY IN BLACKS
LOW INCIDENCE OF IGA NEPHROPATHY IN BLACKS
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DOI：
10.1038/ki.1985.222
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发表时间：
1985-01-01
影响因子：
19.6
通讯作者：
WILKMAN, AS
中科院分区：
文献类型：
--
作者：
JENNETTE, JC;WALL, SD;WILKMAN, AS
对美国东南部连续 1,753 名接受肾活检的患者中发现的 106 名 IgA 肾病患者的临床和病理特征进行了评估。特别关注 IgA 肾病患者中黑人与非 IgA 肾病患者的比例，以及患有 IgA 肾病的白人和黑人之间临床或病理结果的差异。接受肾活检的黑人（461 人中有 6 人）的 IgA 肾病发病率大约比白人（1,292 人中的 100 人）低六倍（P < 0.001）。患有 IgA 肾病的白人和黑人之间没有形态学或免疫组织病理学差异。唯一的临床差异是男女性别比从白人的 3.5:1 变为黑人的 1:5（P < 0.004）。对先前发表的数据的回顾也支持了黑人中 IgA 肾病的低发病率和相反的性别比例。
The clinical and pathologic features were evaluated in 106 IgA nephropathy patients identified in 1,753 consecutive patients undergoing renal biopsy in the southeastern United States. Special attention was paid to the proportion of Blacks among the IgA nephropathy patients compared with non-IgA nephropathy patients, and any differences in clinical or pathologic findings between Whites and Blacks with IgA nephropathy. The incidence of IgA nephropathy was approximately six times lower in Blacks (6 out of 461) than in Whites (100 out of 1,292) undergoing renal biopsy ( P < 0.001). There were no morphologic or immunohistopathologic differences between Whites and Blacks with IgA nephropathy. The only clinical difference was a marked shift in the male to female sex ratio from 3.5:1 in Whites to 1:5 in Blacks (P < 0.004). The low incidence and reversed sex ratio of IgA nephropathy in Blacks were also supported by a review of previously published data.