Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population
Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population
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DOI：
10.1073/pnas.93.21.12035
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发表时间：
1996-10-15
影响因子：
11.1
通讯作者：
Paabo, S
中科院分区：
文献类型：
--
作者：
Sajantila, A;Salem, AH;Paabo, S
在几个欧洲人群的Y染色体单倍型分析揭示了一个几乎单态模式在芬兰人，而Y染色体的多样性显着较高的其他人群。此外，线粒体控制区的核苷酸位置的分析表明，进化缓慢的芬兰人的遗传多样性减少。因此，相对较少的男性和女性贡献了当今芬兰人口中幸存的遗传谱系。这很可能导致了所谓的"芬兰疾病遗产"，芬兰人患上了几种在其他地方很少见的遗传病。对瓶颈之后积累的线粒体突变的初步分析表明，它发生在大约4000年前，大概是当使用农业和畜牧业的人口到达芬兰时。
An analysis of Y-chromosomal haplotypes in several European populations reveals an almost monomorphic pattern in the Finns, whereas Y-chromosomal diversity is significantly higher in other populations. Furthermore, analyses of nucleotide positions in the mitochondrial control region that evolve slowly show a decrease in genetic diversity in Finns. Thus, relatively few men and women have contributed the genetic lineages that today survive in the Finnish population. This is likely to have caused the so-called ''Finnish disease heritage''-i.e., the occurrence of several genetic diseases in the Finnish population that are rare elsewhere. A preliminary analysis of the mitochondrial mutations that have accumulated subsequent to the bottleneck suggests that it occurred about 4000 years ago, presumably when populations using agriculture and animal husbandry arrived in Finland.