Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries
Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries
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DOI：
10.1002/bies.201800008
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发表时间：
2018-06-01
期刊：
影响因子：
4
通讯作者：
Sakai, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Oku, Masahide;Sakai, Yasuyoshi
微自噬最初被定义为溶酶体（空泡）膜动力学，以直接包裹和运输胞质组分进入溶解性细胞器的内腔。微自噬的分子细节一直是未知的，直到在酵母中的遗传研究确定了该过程所需的一组蛋白质。随后对其他实验模式生物的研究导致了一系列发现，伴随着微自噬定义的扩展，也包括内体膜动力学。然而，这些发现仍然对微自噬的分子机制产生了令人困惑的、非整合的图像。通过回顾最近在各种实验系统中对微自噬的研究，我们提出将微自噬分为三种类型，作为发展该过程的全面观点的基础。
Microautophagy is originally defined as lysosomal (vacuolar) membrane dynamics to directly enwrap and transport cytosolic components into the lumen of the lytic organelle. Molecular details of microautophagy had remained unknown until genetic studies in yeast identified a set of proteins required for the process. Subsequent studies with other experimental model organisms resulted in a series of discoveries that accompanied an expansion of the definition of microautophagy to also encompass endosomal membrane dynamics. These findings, however, still impose puzzling, non-integrated images as to the molecular mechanism of microautophagy. By reviewing recent studies on microautophagy in various experimental systems, we propose the classification of microautophagy into three types, as the basis for developing a comprehensive view of the process.