Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease
Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease
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DOI：
10.1038/s41598-018-23424-0
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发表时间：
2018-03-28
影响因子：
4.6
通讯作者：
Brodzki, Jacek
中科院分区：
文献类型：
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作者：
Belchi, Francisco;Pirashvili, Mariam;Brodzki, Jacek
目前可以从医学成像中获得的定量特征并不能提供慢性阻塞性肺疾病(COPD)的完整图像。在本文中，我们介绍了一种新的基于持久同源性的分析工具，它从胸部CT扫描中提取定量特征来描述肺内呼吸道的几何结构。我们表明，这些新的放射学特征与COPD的GOLD指南一致，对COPD患者进行分层，并可以区分吸气和呼气扫描。这些CT测量与目前使用的非常不同，我们证明它们传达了重要的医学信息。这项研究的结果是一个概念的证明，即拓扑学方法可以增强标准方法，以创建更精细的COPD分类，并增加更个性化治疗的可能性。
Quantitative features that can currently be obtained from medical imaging do not provide a complete picture of Chronic Obstructive Pulmonary Disease (COPD). In this paper, we introduce a novel analytical tool based on persistent homology that extracts quantitative features from chest CT scans to describe the geometric structure of the airways inside the lungs. We show that these new radiomic features stratify COPD patients in agreement with the GOLD guidelines for COPD and can distinguish between inspiratory and expiratory scans. These CT measurements are very different to those currently in use and we demonstrate that they convey significant medical information. The results of this study are a proof of concept that topological methods can enhance the standard methodology to create a finer classification of COPD and increase the possibilities of more personalized treatment.