Chronic exposure to biomass fuel smoke and markers of endothelial inflammation.
Chronic exposure to biomass fuel smoke and markers of endothelial inflammation.
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DOI：
10.1111/ina.12259
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发表时间：
2016-10
期刊：
影响因子：
5.8
通讯作者：
Checkley W
中科院分区：
文献类型：
--
作者：
Caravedo MA;Herrera PM;Mongilardi N;de Ferrari A;Davila-Roman VG;Gilman RH;Wise RA;Miele CH;Miranda JJ;Checkley W
室内烟雾暴露可能通过肺介导的炎症、氧化应激和内皮炎症影响心血管疾病（CVD）风险。我们试图探索燃烧生物质燃料的室内烟雾暴露与一组选定的内皮炎症标志物之间的关联。我们比较了生活在秘鲁普诺的228名生物质暴露者与228名非暴露者的血清淀粉样蛋白A蛋白、E-选择素、可溶性ICAM-1和VCAM-1、血管性血友病因子（VWF）和高敏C反应蛋白（hs-CRP）浓度。平均年龄为56岁（SD=13），平均BMI为26.5 kg/m2（SD=4.4），48%为男性，59.4%完成高中学业，2%报告医生诊断为CVD。在未校正的分析中，血清可溶性ICAM-1水平（330对302 ng/mL; p<0.001），可溶性VCAM-1（403对362 ng/mL; p<0.001），E-选择素（54.2对52.7纳克/毫升; p=0.05）分别增加生物质接触与非接触的参与者;而血清vWF（1148 vs. 1311 mU/mL; p<0.001）和hs-CRP（2.56 vs. 3.12 mg/L; p<0.001）水平分别降低。在校正分析中，长期暴露于生物质燃料与血清可溶性ICAM-1（p=0.03）和VCAM-1（p=0.05）和E-选择素（p=0.05）水平呈正相关，与血清vWF（p=0.02）和hs-CRP（p<0.001）水平呈负相关。每日暴露于生物质燃料烟雾与内皮炎症的特定生物标志物的重要差异相关，可能有助于解释慢性暴露者加速动脉粥样硬化。
Indoor smoke exposure may affect cardiovascular disease (CVD) risk via lung-mediated inflammation, oxidative stress, and endothelial inflammation. We sought to explore the association between indoor smoke exposure from burning biomass fuels and a selected group of markers for endothelial inflammation. We compared serum concentrations of amyloid A protein, E-selectin, soluble ICAM-1 and VCAM-1, von Willebrand factor (VWF), and high sensitivity C-reactive protein (hs-CRP) in 228 biomass exposed vs. 228 non-exposed participants living in Puno, Peru. Average age was 56 years (SD=13), average BMI was 26.5 kg/m2 (SD=4.4), 48% were male, 59.4% completed high school and 2% reported a physician diagnosis of CVD. In unadjusted analysis, serum levels of soluble ICAM-1 (330 vs. 302 ng/mL; p<0.001), soluble VCAM-1 (403 vs. 362 ng/mL; p<0.001), and E-selectin (54.2 vs. 52.7 ng/mL; p=0.05) were increased in biomass exposed vs. non-exposed participants, respectively; whereas serum levels of vWF (1148 vs. 1311 mU/mL; p<0.001) and hs-CRP (2.56 vs. 3.12 mg/L; p<0.001) were decreased, respectively. In adjusted analyses, chronic exposure to biomass fuels remained positively associated with serum levels of soluble ICAM-1 (p=0.03) and VCAM-1 (p=0.05) and E-selectin (p=0.05), and remained negatively associated with serum levels of vWF (p=0.02) and hs-CRP (p<0.001). Daily exposure to biomass fuel smoke was associated with important differences in specific biomarkers of endothelial inflammation and may help explain accelerated atherosclerosis among those who are chronically exposed.