Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients
Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients
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DOI：
10.1007/s00421-010-1362-5
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发表时间：
2010-06-01
影响因子：
3
通讯作者：
van Loon, Luc J. C.
中科院分区：
文献类型：
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作者：
Hansen, Dominique;Dendale, Paul;van Loon, Luc J. C.
在肥胖的2型糖尿病患者中观察到血浆游离脂肪酸(FFA)、炎症标志物和脂肪因子浓度的变化。目前尚不清楚这些变化的血浆浓度是否与糖尿病状态或肥胖的存在有关。在这项横断面观察性研究中，我们比较了肥胖型和非肥胖型2型糖尿病患者和健康非肥胖者的基础血浆FFA、炎症标志物和脂肪因子浓度。选择20例健康、血糖正常的男性(体重指数30 kg/m(2))、20例非肥胖者(体重指数30 kg/m(2))和20例肥胖(体重指数35 kg/m(2))2型糖尿病患者作为研究对象。在年龄和习惯性体力活动水平方面进行匹配。评估身体成分、血糖控制和运动能力。测定血浆瘦素、脂联素、抵抗素、肿瘤坏死因子α、白介素6、超敏C反应蛋白和游离脂肪酸浓度。血浆FFA、炎症标志物(hsCRP、IL-6、TNFα)、脂肪因子(脂联素、抵抗素、瘦素)和甘油三酯浓度在非肥胖型糖尿病患者和正常血糖对照组之间没有差异。肥胖糖尿病患者血浆FFA、IL-6、hsCRP、瘦素和甘油三酯水平显著高于正常血糖对照组(P<；0.05)。此外，肥胖组血浆hsCRP和瘦素水平显著高于非肥胖组(P<；0.05)。观察到血浆参数与血糖控制之间的显著相关性，但在校正躯干脂肪组织质量后，相关性消失。血浆瘦素、hsCRP、IL-6和FFA浓度升高与肥胖有关，而与2型糖尿病状态无关。
Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these altered plasma concentrations are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal plasma FFA, inflammatory marker, and adipokine concentrations between obese and non-obese type 2 diabetes patients and healthy, non-obese controls. A total of 20 healthy, normoglycemic males (BMI < 30 kg/m(2)), 20 non-obese (BMI < 30 kg/m(2)) and 20 obese (BMI > 35 kg/m(2)) type 2 diabetes patients were selected to participate in this study. Groups were matched for age and habitual physical activity level. Body composition, glycemic control, and exercise performance capacity were assessed. Basal blood samples were collected to determine plasma leptin, adiponectin, resistin, tumor necrosis factor alpha (TNF alpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and FFA concentrations. Plasma FFA, inflammatory marker (hsCRP, IL-6, TNF alpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls. Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05). Significant correlations between plasma parameters and glycemic control were observed, but disappeared after adjusting for trunk adipose tissue mass. Elevated plasma leptin, hsCRP, IL-6, and FFA concentrations are associated with obesity and not necessarily with the type 2 diabetic state.