Lipid Levels: A Link Between Cardiovascular Disease and Osteoporosis?
Lipid Levels: A Link Between Cardiovascular Disease and Osteoporosis?
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DOI：
10.1359/jbmr.081262
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发表时间：
2009-06-01
影响因子：
6.2
通讯作者：
Eekhoff, Elisabeth M.
中科院分区：
文献类型：
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作者：
Buizert, Petra J.;van Schoor, Natasja M.;Eekhoff, Elisabeth M.
流行病学观察支持心血管疾病（CVD）和骨质疏松症之间的正相关关系，其中胆固醇已被证明是一种可能的联系。只有少数研究调查了血脂和BMD之间的关系，但这种关联仍不清楚。我们研究了血脂与跟骨骨密度的关系。根据阿姆斯特丹纵向老龄化研究的数据进行了一项基于人群的横断面研究，包括620名男性和635名女性，年龄在65-88岁之间。通过定量超声（QUS）、声速（VOS; rills）和宽带超声衰减（BUA; dB/MHz）测量BMD。调整模型的年龄、体重指数、体力活动、吸烟、饮酒、糖尿病、高血压、睾酮和25-羟基维生素D。未发现总胆固醇（TC）与QUS之间存在相关性。高密度脂蛋白胆固醇（HDL-c）最高四分位数的男性和女性与最低四分位数的男性和女性相比，QUS显著较低（男性VOS：β =-20.8，p = 0.00; BUA：β =-5.2，p = 0.02;女性VOS：β =-18.6，p = 0.00）。TC/HDL-c比值与QUS之间存在更强的正相关性（男性-VOS：β = 21.8，p = 0.00; BUA：β = 5.5，p = 0.01;女性-VOS：β = 19.2，p = 0.00; BUA：β = 3.6，p = 0.05）。我们的分析表明，有利于预防CVD的脂质谱（即，高水平HDL-C和低TC/HDL-C比值）不利于QUS。这些结果表明，HDL-C水平不能解释骨质疏松症和CVD之间的关联。骨矿研究杂志2009;24：1103-1109。2008年12月29日在线发布; doi：10.1359/JBMR.081262
Epidemiological observations support a positive relationship between cardiovascular diseases (CVD) and osteoporosis, where cholesterol has been indicated to be a possible link. Only a few studies have investigated the relation between lipids and BMD, but the association remains unclear. We studied the relationship between serum lipids and BMD of the calcaneus. A cross-sectional population-based study was performed, based on data from the Longitudinal Aging Study Amsterdam, including 620 men and 635 women, 65-88 yr of age. BMD was measured by quantitative ultrasound (QUS), velocity of sound (VOS; rills), and broadband ultrasound attenuation (BUA; dB/MHz). Models were adjusted for age, body mass index, physical activity, smoking, alcohol, diabetes mellitus, hypertension, testosterone, and 25-hydroxyvitamin D. No association was found between total cholesterol (TC) and QUS. Men and women in the highest quartile of high-density lipoprotein cholesterol (HDL-c) had a significantly lower QUS (men-VOS: beta = -20.8, p = 0.00; BUA: beta = -5.2, p = 0.02; women-VOS: beta = -18.6, p = 0.00) compared with men and women in the lowest quartile. An even stronger positive association was seen between TC/HDL-c ratio and QUS (men-VOS: beta = 21.8, p = 0.00; BUA: beta = 5.5, p = 0.01; women-VOS: beta = 19.2, p = 0.00; BUA: beta = 3.6, p = 0.05). Our analysis shows that the lipid profile that is favorable in the prevention of CVD (i.e., high levels of HDL-c and low TC/HDL-c ratio) is unfavorable for QUS. These results indicate that HDL-c levels do not explain the association between osteoporosis and CVD. J Bone Miner Res 2009;24:1103-1109. Published online on December 29, 2008; doi: 10.1359/JBMR.081262